Search Results
Overview
| Uniprot ID | Q99608 |
|---|---|
| Protein Name | Necdin |
| Gene Name | NDN |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 201 | ILSLIYVKGRGARES |
Function
Growth suppressor that facilitates the entry of the cell into cell cycle arrest. Functionally similar to the retinoblastoma protein it binds to and represses the activity of cell-cycle-promoting proteins such as SV40 large T antigen, adenovirus E1A, and the transcription factor E2F. Necdin also interacts with p53 and works in an additive manner to inhibit cell growth. Also functions as a transcription factor and directly binds to specific guanosine-rich DNA sequences (By similarity)
Protein Sequence
10
MSEQSKDLSD
20
PNFAAEAPNS
30
EVHSSPGVSE
40
GVPPSATLAE
50
PQSPPLGPTA
60
APQAAPPPQA
70
PNDEGDPKAL
80
QQAAEEGRAH
90
QAPSAAQPGP
100
APPAPAQLVQ
110
KAHELMWYVL
120
VKDQKKMIIW
130
FPDMVKDVIG
140
SYKKWCRSIL
150
RRTSLILARV
160
FGLHLRLTSL
170
HTMEFALVKA
180
LEPEELDRVA
190
LSNRMPMTGL
200
LLMILSLIYV
210
KGRGARESAV
220
WNVLRILGLR
230
PWKKHSTFGD
240
VRKLITEEFV
250
QMNYLKYQRV
260
PYVEPPEYEF
270
FWGSRASREI
280
TKMQIMEFLA
290
RVFKKDPQAW
300
PSRYREALEE
310
ARALREANPT
320
AHYPRSSVSE
D
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0042995 | cell projection |
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0043204 | perikaryon |
| Cellular Component | GO:0032991 | protein-containing complex |
| Molecular Function | GO:0003677 | DNA binding |
| Molecular Function | GO:0043015 | gamma-tubulin binding |
| Molecular Function | GO:1990841 | promoter-specific chromatin binding |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.