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Overview

Uniprot ID	Q99614
Protein Name	Tetratricopeptide repeat protein 1
Gene Name	TTC1
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
44	KNQHSQSKLLRDDEA

Function

Adapter protein that plays a role downstream of GNA15 to stimulate Ras activation and subsequent phosphorylation of ERK1/2 independently of phospholipase Cbeta signaling (PubMed:12748287, PubMed:21486497). Mechanistically, interacts with GNA15 and SOS2 to form a macromolecular signaling complex which has a high affinity for HRAS (PubMed:20639119). Additionally, participates in signaling via other G-alpha proteins like GNA14, activating NF-kappa-B through Ras and ERK pathways (PubMed:22711498). Beyond signaling, supports protein homeostasis by cooperating with HSP40 in the HSP70 chaperone cycle, promoting protein folding through the regulated dissociation of the HSP70 inhibitor HSPBP1 (PubMed:14503850)

Protein Sequence

10 MGEKSENCGV 20 PEDLLNGLKV 30 TDTQEAECAG 40 PPVPDPKNQH 50 SQSKLLRDDE 60 AHLQEDQGEE 70 ECFHDCSASF 80 EEEPGADKVE 90 NKSNEDVNSS 100 ELDEEYLIEL 110 EKNMSDEEKQ 120 KRREESTRLK 130 EEGNEQFKKG 140 DYIEAESSYS 150 RALEMCPSCF 160 QKERSILFSN 170 RAAARMKQDK 180 KEMAINDCSK 190 AIQLNPSYIR 200 AILRRAELYE 210 KTDKLDEALE 220 DYKSILEKDP 230 SIHQAREACM 240 RLPKQIEERN 250 ERLKEEMLGK 260 LKDLGNLVLR 270 PFGLSTENFQ 280 IKQDSSTGSY 290 SINFVQNPNN NR

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005829	cytosol
Cellular Component	GO:0005778	peroxisomal membrane
Molecular Function	GO:0030674	protein-macromolecule adaptor activity
Molecular Function	GO:0051082	unfolded protein binding
Biological Process	GO:0070098	chemokine-mediated signaling pathway
Biological Process	GO:0050729	positive regulation of inflammatory response
Biological Process	GO:0150078	positive regulation of neuroinflammatory response
Biological Process	GO:0006457	protein folding

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.