Search Results

Overview

Uniprot IDQ99623
Protein NameProhibitin-2
Gene NamePHB2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
147 VLKSVVAKFNASQLI
200 YTAAVEAKQVAQQEA
216 RAQFLVEKAKQEQRQ
224 AKQEQRQKIVQAEGE
244 MLGEALSKNPGYIKL
250 SKNPGYIKLRKIRAA
262 RAAQNISKTIATSQN
6 **MAQNLKDLAGRLP
89 DIRARPRKISSPTGS

Function

Protein with pleiotropic attributes mediated in a cell-compartment- and tissue-specific manner, which include the plasma membrane-associated cell signaling functions, mitochondrial chaperone, and transcriptional co-regulator of transcription factors and sex steroid hormones in the nucleus

Protein Sequence

10 MAQNLKDLAG 20 RLPAGPRGMG 30 TALKLLLGAG 40 AVAYGVRESV 50 FTVEGGHRAI 60 FFNRIGGVQQ 70 DTILAEGLHF 80 RIPWFQYPII 90 YDIRARPRKI 100 SSPTGSKDLQ 110 MVNISLRVLS 120 RPNAQELPSM 130 YQRLGLDYEE 140 RVLPSIVNEV 150 LKSVVAKFNA 160 SQLITQRAQV 170 SLLIRRELTE 180 RAKDFSLILD 190 DVAITELSFS 200 REYTAAVEAK 210 QVAQQEAQRA 220 QFLVEKAKQE 230 QRQKIVQAEG 240 EAEAAKMLGE 250 ALSKNPGYIK 260 LRKIRAAQNI 270 SKTIATSQNR 280 IYLTADNLVL 290 NLQDESFTRG SDSLIKGKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0071944 cell periphery
Cellular Component GO:0009986 cell surface
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005743 mitochondrial inner membrane
Cellular Component GO:0005741 mitochondrial outer membrane
Cellular Component GO:0035632 mitochondrial prohibitin complex
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0016363 nuclear matrix
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0032991 protein-containing complex
Molecular Function GO:0033218 amide binding
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0030331 nuclear estrogen receptor binding
Molecular Function GO:0046982 protein heterodimerization activity
Molecular Function GO:0042803 protein homodimerization activity
Molecular Function GO:0046625 sphingolipid binding
Biological Process GO:0140374 antiviral innate immune response
Biological Process GO:0042113 B cell activation
Biological Process GO:0016477 cell migration
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0007005 mitochondrion organization
Biological Process GO:0000423 mitophagy
Biological Process GO:0043066 negative regulation of apoptotic process
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0070374 positive regulation of ERK1 and ERK2 cascade
Biological Process GO:0002639 positive regulation of immunoglobulin production
Biological Process GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction
Biological Process GO:0006606 protein import into nucleus
Biological Process GO:0050821 protein stabilization
Biological Process GO:1900208 regulation of cardiolipin metabolic process
Biological Process GO:0006357 regulation of transcription by RNA polymerase II
Biological Process GO:0039529 RIG-I signaling pathway
Biological Process GO:0007062 sister chromatid cohesion

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.