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Overview

Uniprot IDQ99661
Protein NameKinesin-like protein KIF2C
Gene NameKIF2C
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
104 NSKIPAPKESLRSRS
196 RRKSCLVKEVEKMKN
365 MGGDLSGKAQNASKG
90 QENVTIQKQKRRSVN
92 NVTIQKQKRRSVNSK
99 KRRSVNSKIPAPKES

Function

In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108)

Protein Sequence

10 MAMDSSLQAR 20 LFPGLAIKIQ 30 RSNGLIHSAN 40 VRTVNLEKSC 50 VSVEWAEGGA 60 TKGKEIDFDD 70 VAAINPELLQ 80 LLPLHPKDNL 90 PLQENVTIQK 100 QKRRSVNSKI 110 PAPKESLRSR 120 STRMSTVSEL 130 RITAQENDME 140 VELPAAANSR 150 KQFSVPPAPT 160 RPSCPAVAEI 170 PLRMVSEEME 180 EQVHSIRGSS 190 SANPVNSVRR 200 KSCLVKEVEK 210 MKNKREEKKA 220 QNSEMRMKRA 230 QEYDSSFPNW 240 EFARMIKEFR 250 ATLECHPLTM 260 TDPIEEHRIC 270 VCVRKRPLNK 280 QELAKKEIDV 290 ISIPSKCLLL 300 VHEPKLKVDL 310 TKYLENQAFC 320 FDFAFDETAS 330 NEVVYRFTAR 340 PLVQTIFEGG 350 KATCFAYGQT 360 GSGKTHTMGG 370 DLSGKAQNAS 380 KGIYAMASRD 390 VFLLKNQPCY 400 RKLGLEVYVT 410 FFEIYNGKLF 420 DLLNKKAKLR 430 VLEDGKQQVQ 440 VVGLQEHLVN 450 SADDVIKMID 460 MGSACRTSGQ 470 TFANSNSSRS 480 HACFQIILRA 490 KGRMHGKFSL 500 VDLAGNERGA 510 DTSSADRQTR 520 MEGAEINKSL 530 LALKECIRAL 540 GQNKAHTPFR 550 ESKLTQVLRD 560 SFIGENSRTC 570 MIATISPGIS 580 SCEYTLNTLR 590 YADRVKELSP 600 HSGPSGEQLI 610 QMETEEMEAC 620 SNGALIPGNL 630 SKEEEELSSQ 640 MSSFNEAMTQ 650 IRELEEKAME 660 ELKEIIQQGP 670 DWLELSEMTE 680 QPDYDLETFV 690 NKAESALAQQ 700 AKHFSALRDV 710 IKALRLAMQL 720 EEQASRQISS KKRPQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005813 centrosome
Cellular Component GO:0000775 chromosome, centromeric region
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0005871 kinesin complex
Cellular Component GO:0000776 kinetochore
Cellular Component GO:0016020 membrane
Cellular Component GO:0005874 microtubule
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0035371 microtubule plus-end
Cellular Component GO:0005634 nucleus
Cellular Component GO:0098794 postsynapse
Cellular Component GO:0098793 presynapse
Cellular Component GO:0005819 spindle
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0019237 centromeric DNA binding
Molecular Function GO:0008017 microtubule binding
Molecular Function GO:0003777 microtubule motor activity
Molecular Function GO:0051010 microtubule plus-end binding
Biological Process GO:0051315 attachment of mitotic spindle microtubules to kinetochore
Biological Process GO:0051301 cell division
Biological Process GO:0030951 establishment or maintenance of microtubule cytoskeleton polarity
Biological Process GO:0051310 metaphase chromosome alignment
Biological Process GO:0007019 microtubule depolymerization
Biological Process GO:0007018 microtubule-based movement
Biological Process GO:0007080 mitotic metaphase chromosome alignment
Biological Process GO:0099188 postsynaptic cytoskeleton organization
Biological Process GO:0051983 regulation of chromosome segregation
Biological Process GO:0098696 regulation of neurotransmitter receptor localization to postsynaptic specialization membrane

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.