Overview
| Uniprot ID | Q99685 |
|---|
| Protein Name | Monoglyceride lipase |
|---|
| Gene Name | MGLL |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 245 |
ADRLCDSKGAYLLME |
| 262 |
KSQDKTLKIYEGAYH |
Function
Converts monoacylglycerides to free fatty acids and glycerol (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Hydrolyzes the endocannabinoid 2-arachidonoylglycerol, and thereby contributes to the regulation of endocannabinoid signaling, nociperception and perception of pain (PubMed:19029917, PubMed:20079333, PubMed:21049984, PubMed:22969151, PubMed:24368842). Regulates the levels of fatty acids that serve as signaling molecules and promote cancer cell migration, invasion and tumor growth (PubMed:20079333)
Protein Sequence
10
MPEESSPRRT
20
PQSIPYQDLP
30
HLVNADGQYL
40
FCRYWKPTGT
50
PKALIFVSHG
60
AGEHSGRYEE
70
LARMLMGLDL
80
LVFAHDHVGH
90
GQSEGERMVV
100
SDFHVFVRDV
110
LQHVDSMQKD
120
YPGLPVFLLG
130
HSMGGAIAIL
140
TAAERPGHFA
150
GMVLISPLVL
160
ANPESATTFK
170
VLAAKVLNLV
180
LPNLSLGPID
190
SSVLSRNKTE
200
VDIYNSDPLI
210
CRAGLKVCFG
220
IQLLNAVSRV
230
ERALPKLTVP
240
FLLLQGSADR
250
LCDSKGAYLL
260
MELAKSQDKT
270
LKIYEGAYHV
280
LHKELPEVTN
290
SVFHEINMWV
300
SQRTATAGTA
SPP
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0047372 |
monoacylglycerol lipase activity |
| Molecular Function |
GO:0004622 |
phosphatidylcholine lysophospholipase A1 activity |
| Molecular Function |
GO:0042803 |
protein homodimerization activity |
| Biological Process |
GO:0046464 |
acylglycerol catabolic process |
| Biological Process |
GO:0019369 |
arachidonate metabolic process |
| Biological Process |
GO:0006633 |
fatty acid biosynthetic process |
| Biological Process |
GO:0006954 |
inflammatory response |
| Biological Process |
GO:0006629 |
lipid metabolic process |
| Biological Process |
GO:0052651 |
monoacylglycerol catabolic process |
| Biological Process |
GO:2000124 |
regulation of endocannabinoid signaling pathway |
| Biological Process |
GO:0050727 |
regulation of inflammatory response |
| Biological Process |
GO:0051930 |
regulation of sensory perception of pain |
| Biological Process |
GO:0009966 |
regulation of signal transduction |
| Biological Process |
GO:0019433 |
triglyceride catabolic process |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.