Search Results

Overview

Uniprot IDQ99707
Protein NameMethionine synthase
Gene NameMTR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
717 GPLMNGMKIVGDLFG

Function

Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol (PubMed:16769880, PubMed:17288554, PubMed:27771510). MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate (PubMed:16769880, PubMed:17288554, PubMed:27771510). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:16769880, PubMed:27771510)

Protein Sequence

10 MSPALQDLSQ 20 PEGLKKTLRD 30 EINAILQKRI 40 MVLDGGMGTM 50 IQREKLNEEH 60 FRGQEFKDHA 70 RPLKGNNDIL 80 SITQPDVIYQ 90 IHKEYLLAGA 100 DIIETNTFSS 110 TSIAQADYGL 120 EHLAYRMNMC 130 SAGVARKAAE 140 EVTLQTGIKR 150 FVAGALGPTN 160 KTLSVSPSVE 170 RPDYRNITFD 180 ELVEAYQEQA 190 KGLLDGGVDI 200 LLIETIFDTA 210 NAKAALFALQ 220 NLFEEKYAPR 230 PIFISGTIVD 240 KSGRTLSGQT 250 GEGFVISVSH 260 GEPLCIGLNC 270 ALGAAEMRPF 280 IEIIGKCTTA 290 YVLCYPNAGL 300 PNTFGDYDET 310 PSMMAKHLKD 320 FAMDGLVNIV 330 GGCCGSTPDH 340 IREIAEAVKN 350 CKPRVPPATA 360 FEGHMLLSGL 370 EPFRIGPYTN 380 FVNIGERCNV 390 AGSRKFAKLI 400 MAGNYEEALC 410 VAKVQVEMGA 420 QVLDVNMDDG 430 MLDGPSAMTR 440 FCNLIASEPD 450 IAKVPLCIDS 460 SNFAVIEAGL 470 KCCQGKCIVN 480 SISLKEGEDD 490 FLEKARKIKK 500 YGAAMVVMAF 510 DEEGQATETD 520 TKIRVCTRAY 530 HLLVKKLGFN 540 PNDIIFDPNI 550 LTIGTGMEEH 560 NLYAINFIHA 570 TKVIKETLPG 580 ARISGGLSNL 590 SFSFRGMEAI 600 REAMHGVFLY 610 HAIKSGMDMG 620 IVNAGNLPVY 630 DDIHKELLQL 640 CEDLIWNKDP 650 EATEKLLRYA 660 QTQGTGGKKV 670 IQTDEWRNGP 680 VEERLEYALV 690 KGIEKHIIED 700 TEEARLNQKK 710 YPRPLNIIEG 720 PLMNGMKIVG 730 DLFGAGKMFL 740 PQVIKSARVM 750 KKAVGHLIPF 760 MEKEREETRV 770 LNGTVEEEDP 780 YQGTIVLATV 790 KGDVHDIGKN 800 IVGVVLGCNN 810 FRVIDLGVMT 820 PCDKILKAAL 830 DHKADIIGLS 840 GLITPSLDEM 850 IFVAKEMERL 860 AIRIPLLIGG 870 ATTSKTHTAV 880 KIAPRYSAPV 890 IHVLDASKSV 900 VVCSQLLDEN 910 LKDEYFEEIM 920 EEYEDIRQDH 930 YESLKERRYL 940 PLSQARKSGF 950 QMDWLSEPHP 960 VKPTFIGTQV 970 FEDYDLQKLV 980 DYIDWKPFFD 990 VWQLRGKYPN 1000 RGFPKIFNDK 1010 TVGGEARKVY 1020 DDAHNMLNTL 1030 ISQKKLRARG 1040 VVGFWPAQSI 1050 QDDIHLYAEA 1060 AVPQAAEPIA 1070 TFYGLRQQAE 1080 KDSASTEPYY 1090 CLSDFIAPLH 1100 SGIRDYLGLF 1110 AVACFGVEEL 1120 SKAYEDDGDD 1130 YSSIMVKALG 1140 DRLAEAFAEE 1150 LHERVRRELW 1160 AYCGSEQLDV 1170 ADLRRLRYKG 1180 IRPAPGYPSQ 1190 PDHTEKLTMW 1200 RLADIEQSTG 1210 IRLTESLAMA 1220 PASAVSGLYF 1230 SNLKSKYFAV 1240 GKISKDQVED 1250 YALRKNISVA 1260 EVEKWLGPIL GYDTD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Molecular Function GO:0031419 cobalamin binding
Molecular Function GO:0008705 methionine synthase activity
Molecular Function GO:0008270 zinc ion binding
Biological Process GO:0031103 axon regeneration
Biological Process GO:0071732 cellular response to nitric oxide
Biological Process GO:0009235 cobalamin metabolic process
Biological Process GO:0050667 homocysteine metabolic process
Biological Process GO:0009086 methionine biosynthetic process
Biological Process GO:0032259 methylation
Biological Process GO:0007399 nervous system development
Biological Process GO:0048678 response to axon injury
Biological Process GO:0000096 sulfur amino acid metabolic process
Biological Process GO:0046653 tetrahydrofolate metabolic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.