Search Results
Overview
| Uniprot ID | Q99712 |
|---|---|
| Protein Name | ATP-sensitive inward rectifier potassium channel 15 |
| Gene Name | KCNJ15 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 236 | LLNQATVKFHVDSSS |
Function
Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium
Protein Sequence
10
MDAIHIGMSS
20
TPLVKHTAGA
30
GLKANRPRVM
40
SKSGHSNVRI
50
DKVDGIYLLY
60
LQDLWTTVID
70
MKWRYKLTLF
80
AATFVMTWFL
90
FGVIYYAIAF
100
IHGDLEPGEP
110
ISNHTPCIMK
120
VDSLTGAFLF
130
SLESQTTIGY
140
GVRSITEECP
150
HAIFLLVAQL
160
VITTLIEIFI
170
TGTFLAKIAR
180
PKKRAETIKF
190
SHCAVITKQN
200
GKLCLVIQVA
210
NMRKSLLIQC
220
QLSGKLLQTH
230
VTKEGERILL
240
NQATVKFHVD
250
SSSESPFLIL
260
PMTFYHVLDE
270
TSPLRDLTPQ
280
NLKEKEFELV
290
VLLNATVEST
300
SAVCQSRTSY
310
IPEEIYWGFE
320
FVPVVSLSKN
330
GKYVADFSQF
340
EQIRKSPDCT
350
FYCADSEKQQ
360
LEEKYRQEDQ
370
RERELRTLLL
QQSNV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0034702 | monoatomic ion channel complex |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0005242 | inward rectifier potassium channel activity |
| Biological Process | GO:1990573 | potassium ion import across plasma membrane |
| Biological Process | GO:0006813 | potassium ion transport |
Reference
[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.