Search Results

Overview

Uniprot IDQ99715
Protein NameCollagen alpha-1(XII) chain
Gene NameCOL12A1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1234 EVFDIGPKRVQIALA
1272 AVANLPYKGGNTLTG
1302 GMRPRARKIGVLITD
2377 DEVKSEFKLNTYNDK
2605 QITDRDYKPQVGVIA

Function

Type XII collagen interacts with type I collagen-containing fibrils, the COL1 domain could be associated with the surface of the fibrils, and the COL2 and NC3 domains may be localized in the perifibrillar matrix

Protein Sequence

10 MRSRLPPALA 20 ALGAALLLSS 30 IEAEVDPPSD 40 LNFKIIDENT 50 VHMSWAKPVD 60 PIVGYRITVD 70 PTTDGPTKEF 80 TLSASTTETL 90 LSELVPETEY 100 VVTITSYDEV 110 EESVPVIGQL 120 TIQTGSSTKP 130 VEKKPGKTEI 140 QKCSVSAWTD 150 LVFLVDGSWS 160 VGRNNFKYIL 170 DFIAALVSAF 180 DIGEEKTRVG 190 VVQYSSDTRT 200 EFNLNQYYQR 210 DELLAAIKKI 220 PYKGGNTMTG 230 DAIDYLVKNT 240 FTESAGARVG 250 FPKVAIIITD 260 GKSQDEVEIP 270 ARELRNVGVE 280 VFSLGIKAAD 290 AKELKQIAST 300 PSLNHVFNVA 310 NFDAIVDIQN 320 EIISQVCSGV 330 DEQLGELVSG 340 EEVVEPPSNL 350 IAMEVSSKYV 360 KLNWNPSPSP 370 VTGYKVILTP 380 MTAGSRQHAL 390 SVGPQTTTLS 400 VRDLSADTEY 410 QISVSAMKGM 420 TSSEPISIME 430 KTQPMKVQVE 440 CSRGVDIKAD 450 IVFLVDGSYS 460 IGIANFVKVR 470 AFLEVLVKSF 480 EISPNRVQIS 490 LVQYSRDPHT 500 EFTLKKFTKV 510 EDIIEAINTF 520 PYRGGSTNTG 530 KAMTYVREKI 540 FVPSKGSRSN 550 VPKVMILITD 560 GKSSDAFRDP 570 AIKLRNSDVE 580 IFAVGVKDAV 590 RSELEAIASP 600 PAETHVFTVE 610 DFDAFQRISF 620 ELTQSICLRI 630 EQELAAIKKK 640 AYVPPKDLSF 650 SEVTSYGFKT 660 NWSPAGENVF 670 SYHITYKEAA 680 GDDEVTVVEP 690 ASSTSVVLSS 700 LKPETLYLVN 710 VTAEYEDGFS 720 IPLAGEETTE 730 EVKGAPRNLK 740 VTDETTDSFK 750 ITWTQAPGRV 760 LRYRIIYRPV 770 AGGESREVTT 780 PPNQRRRTLE 790 NLIPDTKYEV 800 SVIPEYFSGP 810 GTPLTGNAAT 820 EEVRGNPRDL 830 RVSDPTTSTM 840 KLSWSGAPGK 850 VKQYLVTYTP 860 VAGGETQEVT 870 VRGDTTNTVL 880 QGLKEGTQYA 890 LSVTALYASG 900 AGDALFGEGT 910 TLEERGSPQD 920 LVTKDITDTS 930 IGAYWTSAPG 940 MVRGYRVSWK 950 SLYDDVDTGE 960 KNLPEDAIHT 970 MIENLQPETK 980 YRISVFATYS 990 SGEGEPLTGD 1000 ATTELSQDSK 1010 TLKVDEETEN 1020 TMRVTWKPAP 1030 GKVVNYRVVY 1040 RPHGRGKQMV 1050 AKVPPTVTST 1060 VLKRLQPQTT 1070 YDITVLPIYK 1080 MGEGKLRQGS 1090 GTTASRFKSP 1100 RNLKTSDPTM 1110 SSFRVTWEPA 1120 PGEVKGYKVT 1130 FHPTGDDRRL 1140 GELVVGPYDN 1150 TVVLEELRAG 1160 TTYKVNVFGM 1170 FDGGESSPLV 1180 GQEMTTLSDT 1190 TVMPILSSGM 1200 ECLTRAEADI 1210 VLLVDGSWSI 1220 GRANFRTVRS 1230 FISRIVEVFD 1240 IGPKRVQIAL 1250 AQYSGDPRTE 1260 WQLNAHRDKK 1270 SLLQAVANLP 1280 YKGGNTLTGM 1290 ALNFIRQQNF 1300 RTQAGMRPRA 1310 RKIGVLITDG 1320 KSQDDVEAPS 1330 KKLKDEGVEL 1340 FAIGIKNADE 1350 VELKMIATDP 1360 DDTHAYNVAD 1370 FESLSRIVDD 1380 LTINLCNSVK 1390 GPGDLEAPSN 1400 LVISERTHRS 1410 FRVSWTPPSD 1420 SVDRYKVEYY 1430 PVSGGKRQEF 1440 YVSRMETSTV 1450 LKDLKPETEY 1460 VVNVYSVVED 1470 EYSEPLKGTE 1480 KTLPVPVVSL 1490 NIYDVGPTTM 1500 HVQWQPVGGA 1510 TGYILSYKPV 1520 KDTEPTRPKE 1530 VRLGPTVNDM 1540 QLTDLVPNTE 1550 YAVTVQAVLH 1560 DLTSEPVTVR 1570 EVTLPLPRPQ 1580 DLKLRDVTHS 1590 TMNVFWEPVP 1600 GKVRKYIVRY 1610 KTPEEDVKEV 1620 EVDRSETSTS 1630 LKDLFSQTLY 1640 TVSVSAVHDE 1650 GESPPVTAQE 1660 TTRPVPAPTN 1670 LKITEVTSEG 1680 FRGTWDHGAS 1690 DVSLYRITWA 1700 PFGSSDKMET 1710 ILNGDENTLV 1720 FENLNPNTIY 1730 EVSITAIYPD 1740 ESESDDLIGS 1750 ERTLPILTTQ 1760 APKSGPRNLQ 1770 VYNATSNSLT 1780 VKWDPASGRV 1790 QKYRITYQPS 1800 TGEGNEQTTT 1810 IGGRQNSVVL 1820 QKLKPDTPYT 1830 ITVSSLYPDG 1840 EGGRMTGRGK 1850 TKPLNTVRNL 1860 RVYDPSTSTL 1870 NVRWDHAEGN 1880 PRQYKLFYAP 1890 AAGGPEELVP 1900 IPGNTNYAIL 1910 RNLQPDTSYT 1920 VTVVPVYTEG 1930 DGGRTSDTGR 1940 TLMRGLARNV 1950 QVYNPTPNSL 1960 DVRWDPAPGP 1970 VLQYRVVYSP 1980 VDGTRPSESI 1990 VVPGNTRMVH 2000 LERLIPDTLY 2010 SVNLVALYSD 2020 GEGNPSPAQG 2030 RTLPRSGPRN 2040 LRVFGETTNS 2050 LSVAWDHADG 2060 PVQQYRIIYS 2070 PTVGDPIDEY 2080 TTVPGRRNNV 2090 ILQPLQPDTP 2100 YKITVIAVYE 2110 DGDGGHLTGN 2120 GRTVGLLPPQ 2130 NIHISDEWYT 2140 RFRVSWDPSP 2150 SPVLGYKIVY 2160 KPVGSNEPME 2170 AFVGEMTSYT 2180 LHNLNPSTTY 2190 DVNVYAQYDS 2200 GLSVPLTDQG 2210 TTLYLNVTDL 2220 KTYQIGWDTF 2230 CVKWSPHRAA 2240 TSYRLKLSPA 2250 DGTRGQEITV 2260 RGSETSHCFT 2270 GLSPDTDYGV 2280 TVFVQTPNLE 2290 GPGVSVKEHT 2300 TVKPTEAPTE 2310 PPTPPPPPTI 2320 PPARDVCKGA 2330 KADIVFLTDA 2340 SWSIGDDNFN 2350 KVVKFIFNTV 2360 GGFDEISPAG 2370 IQVSFVQYSD 2380 EVKSEFKLNT 2390 YNDKALALGA 2400 LQNIRYRGGN 2410 TRTGKALTFI 2420 KEKVLTWESG 2430 MRKNVPKVLV 2440 VVTDGRSQDE 2450 VKKAALVIQQ 2460 SGFSVFVVGV 2470 ADVDYNELAN 2480 IASKPSERHV 2490 FIVDDFESFE 2500 KIEDNLITFV 2510 CETATSSCPL 2520 IYLDGYTSPG 2530 FKMLEAYNLT 2540 EKNFASVQGV 2550 SLESGSFPSY 2560 SAYRIQKNAF 2570 VNQPTADLHP 2580 NGLPPSYTII 2590 LLFRLLPETP 2600 SDPFAIWQIT 2610 DRDYKPQVGV 2620 IADPSSKTLS 2630 FFNKDTRGEV 2640 QTVTFDTEEV 2650 KTLFYGSFHK 2660 VHIVVTSKSV 2670 KIYIDCYEII 2680 EKDIKEAGNI 2690 TTDGYEILGK 2700 LLKGERKSAA 2710 FQIQSFDIVC 2720 SPVWTSRDRC 2730 CDIPSRRDEG 2740 KCPAFPNSCT 2750 CTQDSVGPPG 2760 PPGPAGGPGA 2770 KGPRGERGIS 2780 GAIGPPGPRG 2790 DIGPPGPQGP 2800 PGPQGPNGLS 2810 IPGEQGRQGM 2820 KGDAGEPGLP 2830 GRTGTPGLPG 2840 PPGPMGPPGD 2850 RGFTGKDGAM 2860 GPRGPPGPPG 2870 SPGSPGVTGP 2880 SGKPGKPGDH 2890 GRPGPSGLKG 2900 EKGDRGDIAS 2910 QNMMRAVARQ 2920 VCEQLISGQM 2930 NRFNQMLNQI 2940 PNDYQSSRNQ 2950 PGPPGPPGPP 2960 GSAGARGEPG 2970 PGGRPGFPGT 2980 PGMQGPPGER 2990 GLPGEKGERG 3000 TGSSGPRGLP 3010 GPPGPQGESR 3020 TGPPGSTGSR 3030 GPPGPPGRPG 3040 NSGIRGPPGP 3050 PGYCDSSQCA 3060 SIPYNGQGYP GSG

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005595 collagen type XII trimer
Cellular Component GO:0005788 endoplasmic reticulum lumen
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0031012 extracellular matrix
Cellular Component GO:0005576 extracellular region
Cellular Component GO:0005615 extracellular space
Cellular Component GO:1903561 extracellular vesicle
Molecular Function GO:0030020 extracellular matrix structural constituent conferring tensile strength
Biological Process GO:0007155 cell adhesion
Biological Process GO:0030199 collagen fibril organization
Biological Process GO:0035987 endodermal cell differentiation

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.