Search Results

Overview

Uniprot IDQ99719
Protein NameSeptin-5
Gene NameSEPTIN5
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
10 TGLRYKSKLATPEDK
146 DESGLNRKNIQDNRV
256 SNTVVEAKGQRVRGR
71 LFLTDLYKDRKLLSA
90 SQTVEILKHTVDIEE
98 HTVDIEEKGVKLKLT

Function

Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)

Protein Sequence

10 MSTGLRYKSK 20 LATPEDKQDI 30 DKQYVGFATL 40 PNQVHRKSVK 50 KGFDFTLMVA 60 GESGLGKSTL 70 VHSLFLTDLY 80 KDRKLLSAEE 90 RISQTVEILK 100 HTVDIEEKGV 110 KLKLTIVDTP 120 GFGDAVNNTE 130 CWKPITDYVD 140 QQFEQYFRDE 150 SGLNRKNIQD 160 NRVHCCLYFI 170 SPFGHGLRPV 180 DVGFMKALHE 190 KVNIVPLIAK 200 ADCLVPSEIR 210 KLKERIREEI 220 DKFGIHVYQF 230 PECDSDEDED 240 FKQQDRELKE 250 SAPFAVIGSN 260 TVVEAKGQRV 270 RGRLYPWGIV 280 EVENQAHCDF 290 VKLRNMLIRT 300 HMHDLKDVTC 310 DVHYENYRAH 320 CIQQMTSKLT 330 QDSRMESPIP 340 ILPLPTPDAE 350 TEKLIRMKDE 360 ELRRMQEMLQ RMKQQMQDQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0032153 cell division site
Cellular Component GO:0015630 microtubule cytoskeleton
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0031105 septin complex
Cellular Component GO:0005940 septin ring
Cellular Component GO:0008021 synaptic vesicle
Molecular Function GO:0005525 GTP binding
Molecular Function GO:0003924 GTPase activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0060090 molecular adaptor activity
Molecular Function GO:0005198 structural molecule activity
Biological Process GO:0030534 adult behavior
Biological Process GO:0061640 cytoskeleton-dependent cytokinesis
Biological Process GO:0008104 intracellular protein localization
Biological Process GO:0017157 regulation of exocytosis
Biological Process GO:2000300 regulation of synaptic vesicle exocytosis
Biological Process GO:0035176 social behavior
Biological Process GO:0016080 synaptic vesicle targeting

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.