Search Results
Overview
| Uniprot ID | Q99728 |
|---|---|
| Protein Name | BRCA1-associated RING domain protein 1 |
| Gene Name | BARD1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 160 | KVRYVVSKASVQTQP |
| 334 | RLSSPISKRCRTSIL |
Function
E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage
Protein Sequence
10
MPDNRQPRNR
20
QPRIRSGNEP
30
RSAPAMEPDG
40
RGAWAHSRAA
50
LDRLEKLLRC
60
SRCTNILREP
70
VCLGGCEHIF
80
CSNCVSDCIG
90
TGCPVCYTPA
100
WIQDLKINRQ
110
LDSMIQLCSK
120
LRNLLHDNEL
130
SDLKEDKPRK
140
SLFNDAGNKK
150
NSIKMWFSPR
160
SKKVRYVVSK
170
ASVQTQPAIK
180
KDASAQQDSY
190
EFVSPSPPAD
200
VSERAKKASA
210
RSGKKQKKKT
220
LAEINQKWNL
230
EAEKEDGEFD
240
SKEESKQKLV
250
SFCSQPSVIS
260
SPQINGEIDL
270
LASGSLTESE
280
CFGSLTEVSL
290
PLAEQIESPD
300
TKSRNEVVTP
310
EKVCKNYLTS
320
KKSLPLENNG
330
KRGHHNRLSS
340
PISKRCRTSI
350
LSTSGDFVKQ
360
TVPSENIPLP
370
ECSSPPSCKR
380
KVGGTSGRKN
390
SNMSDEFISL
400
SPGTPPSTLS
410
SSSYRRVMSS
420
PSAMKLLPNM
430
AVKRNHRGET
440
LLHIASIKGD
450
IPSVEYLLQN
460
GSDPNVKDHA
470
GWTPLHEACN
480
HGHLKVVELL
490
LQHKALVNTT
500
GYQNDSPLHD
510
AAKNGHVDIV
520
KLLLSYGASR
530
NAVNIFGLRP
540
VDYTDDESMK
550
SLLLLPEKNE
560
SSSASHCSVM
570
NTGQRRDGPL
580
VLIGSGLSSE
590
QQKMLSELAV
600
ILKAKKYTEF
610
DSTVTHVVVP
620
GDAVQSTLKC
630
MLGILNGCWI
640
LKFEWVKACL
650
RRKVCEQEEK
660
YEIPEGPRRS
670
RLNREQLLPK
680
LFDGCYFYLW
690
GTFKHHPKDN
700
LIKLVTAGGG
710
QILSRKPKPD
720
SDVTQTINTV
730
AYHARPDSDQ
740
RFCTQYIIYE
750
DLCNYHPERV
760
RQGKVWKAPS
770
SWFIDCVMSF
ELLPLDS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0070531 | BRCA1-A complex |
| Cellular Component | GO:0031436 | BRCA1-BARD1 complex |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0016607 | nuclear speck |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0000151 | ubiquitin ligase complex |
| Molecular Function | GO:0140863 | histone H2AK127 ubiquitin ligase activity |
| Molecular Function | GO:0140864 | histone H2AK129 ubiquitin ligase activity |
| Molecular Function | GO:0019900 | kinase binding |
| Molecular Function | GO:0046982 | protein heterodimerization activity |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0061630 | ubiquitin protein ligase activity |
| Molecular Function | GO:0061649 | ubiquitin-modified histone reader activity |
| Molecular Function | GO:0004842 | ubiquitin-protein transferase activity |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0071479 | cellular response to ionizing radiation |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0006281 | DNA repair |
| Biological Process | GO:0110025 | DNA strand resection involved in replication fork processing |
| Biological Process | GO:0035825 | homologous recombination |
| Biological Process | GO:0044818 | mitotic G2/M transition checkpoint |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0045786 | negative regulation of cell cycle |
| Biological Process | GO:0031441 | negative regulation of mRNA 3'-end processing |
| Biological Process | GO:0046826 | negative regulation of protein export from nucleus |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0045732 | positive regulation of protein catabolic process |
| Biological Process | GO:0085020 | protein K6-linked ubiquitination |
| Biological Process | GO:0016567 | protein ubiquitination |
| Biological Process | GO:0051726 | regulation of cell cycle |
| Biological Process | GO:2000001 | regulation of DNA damage checkpoint |
| Biological Process | GO:0006282 | regulation of DNA repair |
| Biological Process | GO:0042325 | regulation of phosphorylation |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0001894 | tissue homeostasis |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.