Search Results

Overview

Uniprot IDQ99729
Protein NameHeterogeneous nuclear ribonucleoprotein A/B
Gene NameHNRNPAB
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
125 KDAASVEKVLDQKEH
130 VEKVLDQKEHRLDGR
215 VKKVLEKKFHTVSGS
223 FHTVSGSKCEIKVAQ
232 EIKVAQPKEVYQQQQ
86 DTSKKDLKDYFTKFG
91 DLKDYFTKFGEVVDC

Function

Binds single-stranded RNA. Has a high affinity for G-rich and U-rich regions of hnRNA. Also binds to APOB mRNA transcripts around the RNA editing site

Protein Sequence

10 MSEAGEEQPM 20 ETTGATENGH 30 EAVPEASRGR 40 GWTGAAAGAG 50 GATAAPPSGN 60 QNGAEGDQIN 70 ASKNEEDAGK 80 MFVGGLSWDT 90 SKKDLKDYFT 100 KFGEVVDCTI 110 KMDPNTGRSR 120 GFGFILFKDA 130 ASVEKVLDQK 140 EHRLDGRVID 150 PKKAMAMKKD 160 PVKKIFVGGL 170 NPESPTEEKI 180 REYFGEFGEI 190 EAIELPMDPK 200 LNKRRGFVFI 210 TFKEEEPVKK 220 VLEKKFHTVS 230 GSKCEIKVAQ 240 PKEVYQQQQY 250 GSGGRGNRNR 260 GNRGSGGGGG 270 GGGQSQSWNQ 280 GYGNYWNQGY 290 GYQQGYGPGY 300 GGYDYSPYGY 310 YGYGPGYDYS 320 QGSTNYGKSQ 330 RRGGHQNNYK PY

Gene Ontology

Classification GO ID Description
Biological Process GO:0010468 regulation of gene expression
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030425 dendrite
Cellular Component GO:0071598 neuronal ribonucleoprotein granule
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Cellular Component GO:1990904 ribonucleoprotein complex
Cellular Component GO:0090575 RNA polymerase II transcription regulator complex
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0044877 protein-containing complex binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:1990837 sequence-specific double-stranded DNA binding
Biological Process GO:0071230 cellular response to amino acid stimulus
Biological Process GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway
Biological Process GO:0001837 epithelial to mesenchymal transition
Biological Process GO:0016556 mRNA modification
Biological Process GO:2000623 negative regulation of nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
Biological Process GO:0045893 positive regulation of DNA-templated transcription
Biological Process GO:0060341 regulation of cellular localization
Biological Process GO:1904580 regulation of intracellular mRNA localization

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.