Search Results

Overview

Uniprot IDQ99733
Protein NameNucleosome assembly protein 1-like 4
Gene NameNAP1L4
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
140 LAGDMKSKVVVTEKA
146 SKVVVTEKAAATAEE
19 SDSVEAAKNASNTEK
26 KNASNTEKLTDQVMQ
64 ETLPKAVKRRINALK
71 KRRINALKQLQVRCA
94 EVHDLERKYAALYQP

Function

Acts as a histone chaperone in nucleosome assembly

Protein Sequence

10 MADHSFSDGV 20 PSDSVEAAKN 30 ASNTEKLTDQ 40 VMQNPRVLAA 50 LQERLDNVPH 60 TPSSYIETLP 70 KAVKRRINAL 80 KQLQVRCAHI 90 EAKFYEEVHD 100 LERKYAALYQ 110 PLFDKRREFI 120 TGDVEPTDAE 130 SEWHSENEEE 140 EKLAGDMKSK 150 VVVTEKAAAT 160 AEEPDPKGIP 170 EFWFTIFRNV 180 DMLSELVQEY 190 DEPILKHLQD 200 IKVKFSDPGQ 210 PMSFVLEFHF 220 EPNDYFTNSV 230 LTKTYKMKSE 240 PDKADPFSFE 250 GPEIVDCDGC 260 TIDWKKGKNV 270 TVKTIKKKQK 280 HKGRGTVRTI 290 TKQVPNESFF 300 NFFNPLKASG 310 DGESLDEDSE 320 FTLASDFEIG 330 HFFRERIVPR 340 AVLYFTGEAI 350 EDDDNFEEGE 360 EGEEEELEGD 370 EEGEDEDDAE INPKV

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000785 chromatin
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0030425 dendrite
Cellular Component GO:0043025 neuronal cell body
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0003682 chromatin binding
Molecular Function GO:0042393 histone binding
Molecular Function GO:0031491 nucleosome binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0051082 unfolded protein binding
Biological Process GO:0006334 nucleosome assembly

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[4] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.

[5] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.

[6] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[7] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[8] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[9] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[10] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[11] Yan M, Tu H, Tang S, Gai Z, Shi Q et al.. Lactylated Proteomic Analysis Reveals Functional Implications of Lysine Lactylation In Asthenozoospermia.. Mol Cell Proteomics 24(12):101439. 2025 Dec. PMID: 41192556.

[12] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.