Overview
| Uniprot ID | Q99735 |
|---|
| Protein Name | Microsomal glutathione S-transferase 2 |
|---|
| Gene Name | MGST2 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 34 |
GKARLKYKVTPPAVT |
Function
Catalyzes several different glutathione-dependent reactions (PubMed:23409838, PubMed:26066610, PubMed:26656251, PubMed:8703034, PubMed:9278457). Catalyzes the glutathione-dependent reduction of lipid hydroperoxides, such as 5-HPETE (PubMed:23409838, PubMed:9278457). Has glutathione transferase activity, toward xenobiotic electrophiles, such as 1-chloro-2, 4-dinitrobenzene (CDNB) (PubMed:23409838, PubMed:8703034). Also catalyzes the conjugation of leukotriene A4 with reduced glutathione to form leukotriene C4 (LTC4) (PubMed:23409838, PubMed:26656251). Involved in oxidative DNA damage induced by ER stress and anticancer agents by activating LTC4 biosynthetic machinery in nonimmune cells (PubMed:26656251)
Protein Sequence
10
MAGNSILLAA
20
VSILSACQQS
30
YFALQVGKAR
40
LKYKVTPPAV
50
TGSPEFERVF
60
RAQQNCVEFY
70
PIFIITLWMA
80
GWYFNQVFAT
90
CLGLVYIYGR
100
HLYFWGYSEA
110
AKKRITGFRL
120
SLGILALLTL
130
LGALGIANSF
140
LDEYLDLNIA
KKLRRQF
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005783 |
endoplasmic reticulum |
| Cellular Component |
GO:0005886 |
plasma membrane |
| Molecular Function |
GO:0008047 |
enzyme activator activity |
| Molecular Function |
GO:0043295 |
glutathione binding |
| Molecular Function |
GO:0004602 |
glutathione peroxidase activity |
| Molecular Function |
GO:0004364 |
glutathione transferase activity |
| Molecular Function |
GO:0042802 |
identical protein binding |
| Molecular Function |
GO:0004464 |
leukotriene-C4 synthase activity |
| Biological Process |
GO:0006750 |
glutathione biosynthetic process |
| Biological Process |
GO:0019370 |
leukotriene biosynthetic process |
| Biological Process |
GO:0006629 |
lipid metabolic process |
| Biological Process |
GO:0046466 |
membrane lipid catabolic process |
| Biological Process |
GO:0050729 |
positive regulation of inflammatory response |
| Biological Process |
GO:0032496 |
response to lipopolysaccharide |
| Cellular Component |
GO:0005789 |
endoplasmic reticulum membrane |
| Cellular Component |
GO:0043231 |
intracellular membrane-bounded organelle |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005635 |
nuclear envelope |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.