Search Results

Overview

Uniprot IDQ99747
Protein NameGamma-soluble NSF attachment protein
Gene NameNAPG
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
123 MALERAGKLIENVDP
15 EGLEHLAKAEKYLKT
159 QAVELLGKASRLLVR
26 YLKTGFLKWKPDYDS
5 ***MAAQKINEGLEH

Function

Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus

Protein Sequence

10 MAAQKINEGL 20 EHLAKAEKYL 30 KTGFLKWKPD 40 YDSAASEYGK 50 AAVAFKNAKQ 60 FEQAKDACLR 70 EAVAHENNRA 80 LFHAAKAYEQ 90 AGMMLKEMQK 100 LPEAVQLIEK 110 ASMMYLENGT 120 PDTAAMALER 130 AGKLIENVDP 140 EKAVQLYQQT 150 ANVFENEERL 160 RQAVELLGKA 170 SRLLVRGRRF 180 DEAALSIQKE 190 KNIYKEIENY 200 PTCYKKTIAQ 210 VLVHLHRNDY 220 VAAERCVRES 230 YSIPGFNGSE 240 DCAALEQLLE 250 GYDQQDQDQV 260 SDVCNSPLFK 270 YMDNDYAKLG 280 LSLVVPGGGI 290 KKKSPATPQA 300 KPDGVTATAA 310 DEEEDEYSGG LC

Gene Ontology

Classification GO ID Description
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005794 Golgi apparatus
Cellular Component GO:0005765 lysosomal membrane
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0031201 SNARE complex
Molecular Function GO:0005483 soluble NSF attachment protein activity
Molecular Function GO:0019905 syntaxin binding
Biological Process GO:0006891 intra-Golgi vesicle-mediated transport
Biological Process GO:0006886 intracellular protein transport
Biological Process GO:0061025 membrane fusion
Biological Process GO:0050821 protein stabilization
Biological Process GO:0065003 protein-containing complex assembly

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.