Search Results

Overview

Uniprot IDQ99798
Protein NameAconitate hydratase, mitochondrial
Gene NameACO2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
138 EAQVGGEKDLRRAKD
144 EKDLRRAKDINQEVY
31 SVLCQRAKVAMSHFE
370 EVGKVAEKEGWPLDI
401 GRSAAVAKQALAHGL
409 QALAHGLKCKSQFTI
50 IHYDLLEKNINIVRK
520 YLTGTDGKKFRLEAP
534 PDADELPKGEFDPGQ
549 DTYQHPPKDSSGQHV
591 ILIKVKGKCTTDHIS
628 AINIENGKANSVRNA
68 RPLTLSEKIVYGHLD
689 GGRAIITKSFARIHE
717 ADPADYNKIHPVDKL
723 NKIHPVDKLTIQGLK
730 KLTIQGLKDFTPGKP
736 LKDFTPGKPLKCIIK

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate

Protein Sequence

10 MAPYSLLVTR 20 LQKALGVRQY 30 HVASVLCQRA 40 KVAMSHFEPN 50 EYIHYDLLEK 60 NINIVRKRLN 70 RPLTLSEKIV 80 YGHLDDPASQ 90 EIERGKSYLR 100 LRPDRVAMQD 110 ATAQMAMLQF 120 ISSGLSKVAV 130 PSTIHCDHLI 140 EAQVGGEKDL 150 RRAKDINQEV 160 YNFLATAGAK 170 YGVGFWKPGS 180 GIIHQIILEN 190 YAYPGVLLIG 200 TDSHTPNGGG 210 LGGICIGVGG 220 ADAVDVMAGI 230 PWELKCPKVI 240 GVKLTGSLSG 250 WSSPKDVILK 260 VAGILTVKGG 270 TGAIVEYHGP 280 GVDSISCTGM 290 ATICNMGAEI 300 GATTSVFPYN 310 HRMKKYLSKT 320 GREDIANLAD 330 EFKDHLVPDP 340 GCHYDQLIEI 350 NLSELKPHIN 360 GPFTPDLAHP 370 VAEVGKVAEK 380 EGWPLDIRVG 390 LIGSCTNSSY 400 EDMGRSAAVA 410 KQALAHGLKC 420 KSQFTITPGS 430 EQIRATIERD 440 GYAQILRDLG 450 GIVLANACGP 460 CIGQWDRKDI 470 KKGEKNTIVT 480 SYNRNFTGRN 490 DANPETHAFV 500 TSPEIVTALA 510 IAGTLKFNPE 520 TDYLTGTDGK 530 KFRLEAPDAD 540 ELPKGEFDPG 550 QDTYQHPPKD 560 SSGQHVDVSP 570 TSQRLQLLEP 580 FDKWDGKDLE 590 DLQILIKVKG 600 KCTTDHISAA 610 GPWLKFRGHL 620 DNISNNLLIG 630 AINIENGKAN 640 SVRNAVTQEF 650 GPVPDTARYY 660 KKHGIRWVVI 670 GDENYGEGSS 680 REHAALEPRH 690 LGGRAIITKS 700 FARIHETNLK 710 KQGLLPLTFA 720 DPADYNKIHP 730 VDKLTIQGLK 740 DFTPGKPLKC 750 IIKHPNGTQE 760 TILLNHTFNE 770 TQIEWFRAGS 780 ALNRMKELQQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0003994 aconitate hydratase activity
Molecular Function GO:0005506 iron ion binding
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0006091 generation of precursor metabolites and energy
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.