Search Results
Overview
| Uniprot ID | Q99848 |
|---|---|
| Protein Name | Probable rRNA-processing protein EBP2 |
| Gene Name | EBNA1BP2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | LPRLHQLKVPTKRPT |
| 149 | KSDLQMQKIRQKLQT |
| 157 | IRQKLQTKQAAMERS |
| 179 | ALRKYGKKVQTEVLQ |
| 187 | VQTEVLQKRQQEKAH |
| 204 | NAIKKYQKGFSDKLD |
| 247 | KRRYKNQKFGFGGKK |
| 258 | GGKKKGSKWNTRESY |
Function
Required for the processing of the 27S pre-rRNA
Protein Sequence
10
MDTPPLSDSE
20
SESDESLVTD
30
RELQDAFSRG
40
LLKPGLNVVL
50
EGPKKAVNDV
60
NGLKQCLAEF
70
KRDLEWVERL
80
DVTLGPVPEI
90
GGSEAPAPQN
100
KDQKAVDPED
110
DFQREMSFYR
120
QAQAAVLAVL
130
PRLHQLKVPT
140
KRPTDYFAEM
150
AKSDLQMQKI
160
RQKLQTKQAA
170
MERSEKAKQL
180
RALRKYGKKV
190
QTEVLQKRQQ
200
EKAHMMNAIK
210
KYQKGFSDKL
220
DFLEGDQKPL
230
AQRKKAGAKG
240
QQMRKGPSAK
250
RRYKNQKFGF
260
GGKKKGSKWN
270
TRESYDDVSS
280
FRAKTAHGRG
290
LKRPGKKGSN
300
KRPGKRTREK
MKNRTH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005694 | chromosome |
| Cellular Component | GO:0034399 | nuclear periphery |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0030687 | preribosome, large subunit precursor |
| Molecular Function | GO:0003723 | RNA binding |
| Biological Process | GO:0042273 | ribosomal large subunit biogenesis |
| Biological Process | GO:0006364 | rRNA processing |
Reference
[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.