Search Results
Overview
| Uniprot ID | Q99873 |
|---|---|
| Protein Name | Protein arginine N-methyltransferase 1 |
| Gene Name | PRMT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 113 | AAKAGARKVIGIECS |
| 145 | VVTIIKGKVEEVELP |
Function
Arginine methyltransferase that methylates (mono and asymmetric dimethylation) the guanidino nitrogens of arginyl residues present in proteins such as ESR1, histone H2, H3 and H4, FMR1, ILF3, HNRNPA1, HNRNPD, NFATC2IP, SUPT5H, TAF15, EWS, HABP4, SERBP1, RBM15, FOXO1, CHTOP, MAP3K5/ASK1, MICU1 and NPRL2 (PubMed:10749851, PubMed:15741314, PubMed:16879614, PubMed:18951090, PubMed:22095282, PubMed:25284789, PubMed:26575292, PubMed:26876602, PubMed:27642082, PubMed:30765518, PubMed:31257072, PubMed:38006878). Constitutes the main enzyme that mediates monomethylation and asymmetric dimethylation of histone H4 'Arg-3' (H4R3me1 and H4R3me2a, respectively), a specific tag for epigenetic transcriptional activation. May be involved in the regulation of TAF15 transcriptional activity, act as an activator of estrogen receptor (ER)-mediated transactivation, play a key role in neurite outgrowth and act as a negative regulator of megakaryocytic differentiation, by modulating p38 MAPK pathway. Methylates RBM15, promoting ubiquitination and degradation of RBM15 (PubMed:26575292). Methylates MRE11 and TP53BP1, promoting the DNA damage response (PubMed:15741314, PubMed:16294045, PubMed:29651020). Methylates FOXO1 and retains it in the nucleus increasing its transcriptional activity (PubMed:18951090). Methylates CHTOP and this methylation is critical for its 5-hydroxymethylcytosine (5hmC)-binding activity (PubMed:25284789). Methylates MAP3K5/ASK1 at 'Arg-78' and 'Arg-80' which promotes association of MAP3K5 with thioredoxin and negatively regulates MAP3K5 association with TRAF2, inhibiting MAP3K5 stimulation and MAP3K5-induced activation of JNK (PubMed:22095282). Methylates H4R3 in genes involved in glioblastomagenesis in a CHTOP- and/or TET1-dependent manner (PubMed:25284789). Plays a role in regulating alternative splicing in the heart (By similarity). Methylates NPRL2 at 'Arg-78' leading to inhibition of its GTPase activator activity and then the GATOR1 complex and consequently inducing timely mTORC1 activation under methionine-sufficient conditions (PubMed:38006878). Methylates the C-terminus of DSP, promoting its phosphorylation by GSK3B and subsequent recruitment to desmosome cell-cell junctions (PubMed:25733715)
Protein Sequence
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0019899 | enzyme binding |
| Molecular Function | GO:0106080 | GATOR1 complex binding |
| Molecular Function | GO:0044020 | histone H4R3 methyltransferase activity |
| Molecular Function | GO:0042054 | histone methyltransferase activity |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008327 | methyl-CpG binding |
| Molecular Function | GO:0048273 | mitogen-activated protein kinase p38 binding |
| Molecular Function | GO:0008170 | N-methyltransferase activity |
| Molecular Function | GO:0008276 | protein methyltransferase activity |
| Molecular Function | GO:0016274 | protein-arginine N-methyltransferase activity |
| Molecular Function | GO:0035242 | protein-arginine omega-N asymmetric methyltransferase activity |
| Molecular Function | GO:0035241 | protein-arginine omega-N monomethyltransferase activity |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:1904047 | S-adenosyl-L-methionine binding |
| Biological Process | GO:0048738 | cardiac muscle tissue development |
| Biological Process | GO:0007166 | cell surface receptor signaling pathway |
| Biological Process | GO:0061431 | cellular response to methionine |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0046329 | negative regulation of JNK cascade |
| Biological Process | GO:0045653 | negative regulation of megakaryocyte differentiation |
| Biological Process | GO:0031175 | neuron projection development |
| Biological Process | GO:0018216 | peptidyl-arginine methylation |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:1905168 | positive regulation of double-strand break repair via homologous recombination |
| Biological Process | GO:0045648 | positive regulation of erythrocyte differentiation |
| Biological Process | GO:0046985 | positive regulation of hemoglobin biosynthetic process |
| Biological Process | GO:1900745 | positive regulation of p38MAPK cascade |
| Biological Process | GO:1904263 | positive regulation of TORC1 signaling |
| Biological Process | GO:0045727 | positive regulation of translation |
| Biological Process | GO:0051260 | protein homooligomerization |
| Biological Process | GO:0006479 | protein methylation |
| Biological Process | GO:0030510 | regulation of BMP signaling pathway |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0045652 | regulation of megakaryocyte differentiation |
| Biological Process | GO:0008380 | RNA splicing |
| Biological Process | GO:0019082 | viral protein processing |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005765 | lysosomal membrane |
| Cellular Component | GO:0034709 | methylosome |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.
[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.