Search Results
Overview
| Uniprot ID | Q99952 |
|---|---|
| Protein Name | Tyrosine-protein phosphatase non-receptor type 18 |
| Gene Name | PTPN18 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 391 | EEAPLYSKVTPRAQR |
Function
Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues
Protein Sequence
10
MSRSLDSARS
20
FLERLEARGG
30
REGAVLAGEF
40
SDIQACSAAW
50
KADGVCSTVA
60
GSRPENVRKN
70
RYKDVLPYDQ
80
TRVILSLLQE
90
EGHSDYINGN
100
FIRGVDGSLA
110
YIATQGPLPH
120
TLLDFWRLVW
130
EFGVKVILMA
140
CREIENGRKR
150
CERYWAQEQE
160
PLQTGLFCIT
170
LIKEKWLNED
180
IMLRTLKVTF
190
QKESRSVYQL
200
QYMSWPDRGV
210
PSSPDHMLAM
220
VEEARRLQGS
230
GPEPLCVHCS
240
AGCGRTGVLC
250
TVDYVRQLLL
260
TQMIPPDFSL
270
FDVVLKMRKQ
280
RPAAVQTEEQ
290
YRFLYHTVAQ
300
MFCSTLQNAS
310
PHYQNIKENC
320
APLYDDALFL
330
RTPQALLAIP
340
RPPGGVLRSI
350
SVPGSPGHAM
360
ADTYAVVQKR
370
GAPAGAGSGT
380
QTGTGTGTGA
390
RSAEEAPLYS
400
KVTPRAQRPG
410
AHAEDARGTL
420
PGRVPADQSP
430
AGSGAYEDVA
440
GGAQTGGLGF
450
NLRIGRPKGP
460
RDPPAEWTRV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0004726 | non-membrane spanning protein tyrosine phosphatase activity |
| Molecular Function | GO:0004725 | protein tyrosine phosphatase activity |
| Biological Process | GO:1901185 | negative regulation of ERBB signaling pathway |
| Biological Process | GO:0006470 | protein dephosphorylation |
Reference
PMID: N/A