Search Results
Overview
| Uniprot ID | Q99962 |
|---|---|
| Protein Name | Endophilin-A1 |
| Gene Name | SH3GL2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 149 | PLQNLHDKDLREIQH |
| 171 | RRLDFDYKKKRQGKI |
| 177 | YKKKRQGKIPDEELR |
| 189 | ELRQALEKFDESKEI |
| 20 | ATQKVSEKVGGAEGT |
| 7 | *MSVAGLKKQFHKAT |
| 82 | SKIRGQEKGPGYPQA |
Function
Implicated in endocytosis. Involved ultrafast endocytosis, by mediating, in a first step, neck formation and in a second step, aids in the removal of clathrin coats from the regenerated vesicles. May recruit other proteins to membranes with high curvature. Required for BDNF-dependent dendrite outgrowth. Cooperates with SH3GL2 to mediate BDNF-NTRK2 early endocytic trafficking and signaling from early endosomes
Protein Sequence
10
MSVAGLKKQF
20
HKATQKVSEK
30
VGGAEGTKLD
40
DDFKEMERKV
50
DVTSRAVMEI
60
MTKTIEYLQP
70
NPASRAKLSM
80
INTMSKIRGQ
90
EKGPGYPQAE
100
ALLAEAMLKF
110
GRELGDDCNF
120
GPALGEVGEA
130
MRELSEVKDS
140
LDIEVKQNFI
150
DPLQNLHDKD
160
LREIQHHLKK
170
LEGRRLDFDY
180
KKKRQGKIPD
190
EELRQALEKF
200
DESKEIAESS
210
MFNLLEMDIE
220
QVSQLSALVQ
230
AQLEYHKQAV
240
QILQQVTVRL
250
EERIRQASSQ
260
PRREYQPKPR
270
MSLEFPTGDS
280
TQPNGGLSHT
290
GTPKPSGVQM
300
DQPCCRALYD
310
FEPENEGELG
320
FKEGDIITLT
330
NQIDENWYEG
340
MLHGHSGFFP
350
INYVEILVAL
PH
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Biological Process | GO:0031175 | neuron projection development |
| Cellular Component | GO:0030669 | clathrin-coated endocytic vesicle membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005769 | early endosome |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0048471 | perinuclear region of cytoplasm |
| Cellular Component | GO:0098684 | photoreceptor ribbon synapse |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0098794 | postsynapse |
| Cellular Component | GO:0098793 | presynapse |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0008289 | lipid binding |
| Molecular Function | GO:0030674 | protein-macromolecule adaptor activity |
| Biological Process | GO:1990416 | cellular response to brain-derived neurotrophic factor stimulus |
| Biological Process | GO:0007417 | central nervous system development |
| Biological Process | GO:0097484 | dendrite extension |
| Biological Process | GO:0097749 | membrane tubulation |
| Biological Process | GO:1905604 | negative regulation of blood-brain barrier permeability |
| Biological Process | GO:0042059 | negative regulation of epidermal growth factor receptor signaling pathway |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0043409 | negative regulation of MAPK cascade |
| Biological Process | GO:0098974 | postsynaptic actin cytoskeleton organization |
| Biological Process | GO:0007165 | signal transduction |
| Biological Process | GO:0048488 | synaptic vesicle endocytosis |
Reference
[1] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.