Search Results

Overview

Uniprot ID	Q99J39
Protein Name	Malonyl-CoA decarboxylase, mitochondrial
Gene Name	Mlycd
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
227	VKNWMDMKRRVGPYR
385	LSSGEWVKSEKLTQA
388	GEWVKSEKLTQALQG

Function

Catalyzes the conversion of malonyl-CoA to acetyl-CoA. In the fatty acid biosynthesis MCD selectively removes malonyl-CoA and thus assures that methyl-malonyl-CoA is the only chain elongating substrate for fatty acid synthase and that fatty acids with multiple methyl side chains are produced. In peroxisomes it may be involved in degrading intraperoxisomal malonyl-CoA, which is generated by the peroxisomal beta-oxidation of odd chain-length dicarboxylic fatty acids. Plays a role in the metabolic balance between glucose and lipid oxidation in muscle independent of alterations in insulin signaling. Plays a role in controlling the extent of ischemic injury by promoting glucose oxidation

Protein Sequence

10 MRGLGPGLRA 20 RRLLPLRSPP 30 RPPGPRGRRL 40 CGGLAASAMD 50 ELLRRAVPPT 60 PAYELREKTP 70 APAEGQCADF 80 VSFYGGLAEA 90 SQRAELLGRL 100 AQGFGVDHGQ 110 VAEQSAGVLQ 120 LRQQAREAAV 130 LLQAEDRLRY 140 ALVPRYRGLF 150 HHISKLDGGV 160 RFLVQLRADL 170 LEAQALKLVE 180 GPHVREMNGV 190 LKSMLSEWFS 200 SGFLNLERVT 210 WHSPCEVLQK 220 ISECEAVHPV 230 KNWMDMKRRV 240 GPYRRCYFFS 250 HCSTPGEPLV 260 VLHVALTGDI 270 SNNIQGIVKE 280 CPPTETEERN 290 RIAAAIFYSI 300 SLTQQGLQGV 310 ELGTFLIKRV 320 VKELQKEFPQ 330 LGAFSSLSPI 340 PGFTKWLLGL 350 LNVQGKEHGR 360 NELFTDSECQ 370 EISAVTGNPV 380 HESLKGFLSS 390 GEWVKSEKLT 400 QALQGPLMRL 410 CAWYLYGEKH 420 RGYALNPVAN 430 FHLQNGAVMW 440 RINWMADSSL 450 KGLTSSCGLM 460 VNYRYYLEET 470 GPNSISYLGS 480 KNIKASEQIL 490 SLVAQFQNNS KL

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005737	cytoplasm
Cellular Component	GO:0005759	mitochondrial matrix
Cellular Component	GO:0005739	mitochondrion
Cellular Component	GO:0005782	peroxisomal matrix
Cellular Component	GO:0005777	peroxisome
Molecular Function	GO:0042802	identical protein binding
Molecular Function	GO:0050080	malonyl-CoA decarboxylase activity
Biological Process	GO:0006085	acetyl-CoA biosynthetic process
Biological Process	GO:0006633	fatty acid biosynthetic process
Biological Process	GO:0019395	fatty acid oxidation
Biological Process	GO:2001294	malonyl-CoA catabolic process
Biological Process	GO:0046321	positive regulation of fatty acid oxidation
Biological Process	GO:0031998	regulation of fatty acid beta-oxidation
Biological Process	GO:0046320	regulation of fatty acid oxidation
Biological Process	GO:0010906	regulation of glucose metabolic process
Biological Process	GO:0002931	response to ischemia
Biological Process	GO:0007584	response to nutrient

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.