Search Results
Overview
| Uniprot ID | Q99JF8 |
|---|---|
| Protein Name | PC4 and SFRS1-interacting protein |
| Gene Name | Psip1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 200 | RGRPKVVKQPCPSDG |
| 405 | LKKIRRFKVSQVIME |
Function
Transcriptional coactivator involved in neuroepithelial stem cell differentiation and neurogenesis. Involved in particular in lens epithelial cell gene regulation and stress responses. May play an important role in lens epithelial to fiber cell terminal differentiation. May play a protective role during stress-induced apoptosis (By similarity)
Protein Sequence
10
MTRDFKPGDL
20
IFAKMKGYPH
30
WPARVDEVPD
40
GAVKPPTNKL
50
PIFFFGTHET
60
AFLGPKDIFP
70
YSENKEKYGK
80
PNKRKGFNEG
90
LWEIDNNPKV
100
KFSSQQASTK
110
QSNASSDVEV
120
EEKETNVSKE
130
DTDQEEKASN
140
EDVTKAVDIT
150
TPKAARRGRK
160
RKAEKQVDTE
170
EAGMVTAATA
180
SNVKASPKRG
190
RPAATEVKIP
200
KPRGRPKVVK
210
QPCPSDGDMV
220
IDEDKSKKKG
230
PEEKQPKKQL
240
KKEEEGQKEE
250
EKPRKEPDKK
260
EGKKEVESKR
270
KNLAKPGVTS
280
TSDSEDEDDQ
290
EGEKKRKGGR
300
NFQAAHRRNM
310
LKGQHEKEAG
320
DRKRKQEEQM
330
ETEQQNKDEG
340
KKPEVKKVEK
350
KRETSMDSRL
360
QRIHAEIKNS
370
LKIDNLDVNR
380
CIEALDELAS
390
LQVTMQQAQK
400
HTEMITTLKK
410
IRRFKVSQVI
420
MEKSTMLYNK
430
FKNMFLVGEG
440
DSVITQVLNK
450
SLAEQRQHEE
460
ANKTKDQGKK
470
GPNKKLEKEP
480
TGTKSLNGGS
490
DAQESNHPQH
500
NGDSNEDGKD
510
SREASSKTKP
520
PGEEREAEIS
LKESTLDN
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000791 | euchromatin |
| Cellular Component | GO:0000792 | heterochromatin |
| Cellular Component | GO:0034399 | nuclear periphery |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0003682 | chromatin binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0097100 | supercoiled DNA binding |
| Molecular Function | GO:0003713 | transcription coactivator activity |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0006351 | DNA-templated transcription |
| Biological Process | GO:0000395 | mRNA 5'-splice site recognition |
| Biological Process | GO:0045944 | positive regulation of transcription by RNA polymerase II |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0006979 | response to oxidative stress |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.