Search Results
Overview
| Uniprot ID | Q99KB8 |
|---|---|
| Protein Name | Hydroxyacylglutathione hydrolase, mitochondrial |
| Gene Name | Hagh |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 114 | DHAGGNEKLVKLEPG |
| 117 | GGNEKLVKLEPGLKV |
Function
Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid
Protein Sequence
10
MVLGRGSLCL
20
RSLSALGATC
30
ARRGLGQALL
40
GLSLCHSDFR
50
KNLTVQQDIM
60
KVELLPALTD
70
NYMYLIIDED
80
TQEAAIVDPV
90
QPQKVIEAAK
100
KHHVKLTTVL
110
TTHHHWDHAG
120
GNEKLVKLEP
130
GLKVYGGDDR
140
IGALTHKVTH
150
LSTLQVGSLS
160
VKCLSTPCHT
170
SGHICYFVSK
180
PGSSEPSAVF
190
TGDTLFVAGC
200
GKFYEGTADE
210
MYKALLEVLG
220
RLPPDTKVYC
230
GHEYTVNNLK
240
FARHVEPGNA
250
AIQEKLAWAK
260
EKYAIGEPTV
270
PSTLAEEFTY
280
NPFMRVKEKT
290
VQQHAGETDP
300
VTTMRAIRRE
KDQFKVPRD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Molecular Function | GO:0004416 | hydroxyacylglutathione hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Biological Process | GO:0006750 | glutathione biosynthetic process |
| Biological Process | GO:0006749 | glutathione metabolic process |
| Biological Process | GO:0019243 | methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.