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Overview

Uniprot ID	Q99KC8
Protein Name	von Willebrand factor A domain-containing protein 5A
Gene Name	Vwa5a
Organism	Mus musculus

Kla Sites from experimental identification

Position	Flanking peptide
664	SACSAIQKKKTNSST

Function

May play a role in tumorigenesis as a tumor suppressor. Altered expression of this protein and disruption of the molecular pathway it is involved in may contribute directly to or modify tumorigenesis (By similarity)

Protein Sequence

10 MEHHCGLITS 20 NKETVPLKNI 30 SVTLSINEFV 40 AAVVATLNYE 50 NEEKVPLEAT 60 FVFPMDEDSA 70 VYSFEALVDG 80 KKIVAELQDK 90 MKAHSEYEEA 100 LSQGHQAYLL 110 EEDDYSRDVF 120 SCNVGNLQPG 130 AKVAVTLRYV 140 QELPLETDGA 150 LRYLLPAILN 160 PRYQLSEQSA 170 NSCLNIQKPT 180 VPLEDLPYTL 190 NMTATITSQH 200 GIERVQSNCS 210 LSPIQYLTDD 220 KTSAQVSLTE 230 GHKFDRDVEL 240 LIYYNEVHSP 250 SVAVEMGMLD 260 MKPDSLMGAP 270 SAMVSFYPDI 280 PEVEASKACG 290 EFVFLMDRSG 300 SMDSPMSTEN 310 NSQLRIEAAK 320 ETLLLLLKSL 330 PMGCYFNIYG 340 FGSSYEKFFP 350 ESVKYTQDTM 360 EDAVKRVKAL 370 KANLGGTEIL 380 TPLCNIYKAS 390 SIPGHPLQLF 400 VFTDGEVSDT 410 FSVIREVKLN 420 SKKHRCFSFG 430 IGQGASTSLI 440 KNIARVSGGT 450 AVFITGKDRM 460 QTKALGSLKF 470 ALQCAVDNIS 480 LSWDLPPGLS 490 VKMLSPEQLT 500 IFRGQRLIIY 510 AQLTGLMPQV 520 ESTGAVCLKH 530 ILQGRSLENR 540 VTFSLQPKAN 550 DNFTIHRLAA 560 KSLIQTKDFG 570 SQEASKEEKE 580 DVMNISLQSG 590 VLSSFTAFIA 600 INKELNKPVQ 610 GPLAHRVIPR 620 PVMAGSSSMR 630 FYSSFSGGFK 640 GPQPRSLRVP 650 AYDLCSAESA 660 NLVLKKSACS 670 AIQKKKTNSS 680 TNKSNLKKEH 690 KAFGENAVVQ 700 LISLQKANGS 710 WELDEDLTKI 720 LGTKSKDIKA 730 ANPAKHEDPS 740 AWSTVLAVVW 750 LHANGTDLKC 760 EWELLERKAV 770 AWLHDHAGSS 780 IPMLVQAANS 790 LLKLSVNPAV FGV

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0031012	extracellular matrix
Cellular Component	GO:0005654	nucleoplasm

Reference

[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.