Search Results

Overview

Uniprot IDQ99KI0
Protein NameAconitate hydratase, mitochondrial
Gene NameAco2
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
138 EAQVGGEKDLRRAKD
144 EKDLRRAKDINQEVY
228 PWELKCPKVIGVKLT
309 RMKKYLSKTGRTDIA
31 SVLCQRAKVAMSHFE
401 GRSAAVAKQALAHGL
409 QALAHGLKCKSQFTI
411 LAHGLKCKSQFTITP
462 WDRKDIKKGEKNTIV
465 KDIKKGEKNTIVTSY
50 IRYDLLEKNINIVRK
517 ETDFLTGKDGKKFKL
520 FLTGKDGKKFKLEAP
523 GKDGKKFKLEAPDAD
549 DTYQHPPKDSSGQRV
573 QLLEPFDKWDGKDLE
591 ILIKVKGKCTTDHIS
605 SAAGPWLKFRGHLDN
689 GGRAIITKSFARIHE
700 RIHETNLKKQGLLPL
723 NKIHPVDKLTIQGLK
730 KLTIQGLKDFAPGKP
736 LKDFAPGKPLKCVIK
739 FAPGKPLKCVIKHPN

Function

Catalyzes the isomerization of citrate to isocitrate via cis-aconitate

Protein Sequence

10 MAPYSLLVTR 20 LQKALGVRQY 30 HVASVLCQRA 40 KVAMSHFEPS 50 EYIRYDLLEK 60 NINIVRKRLN 70 RPLTLSEKIV 80 YGHLDDPANQ 90 EIERGKTYLR 100 LRPDRVAMQD 110 ATAQMAMLQF 120 ISSGLPKVAV 130 PSTIHCDHLI 140 EAQVGGEKDL 150 RRAKDINQEV 160 YNFLATAGAK 170 YGVGFWRPGS 180 GIIHQIILEN 190 YAYPGVLLIG 200 TDSHTPNGGG 210 LGGICIGVGG 220 ADAVDVMAGI 230 PWELKCPKVI 240 GVKLTGSLSG 250 WTSPKDVILK 260 VAGILTVKGG 270 TGAIVEYHGP 280 GVDSISCTGM 290 ATICNMGAEI 300 GATTSVFPYN 310 HRMKKYLSKT 320 GRTDIANLAE 330 EFKDHLVPDP 340 GCQYDQVIEI 350 NLNELKPHIN 360 GPFTPDLAHP 370 VADVGTVAEK 380 EGWPLDIRVG 390 LIGSCTNSSY 400 EDMGRSAAVA 410 KQALAHGLKC 420 KSQFTITPGS 430 EQIRATIERD 440 GYAQILRDVG 450 GIVLANACGP 460 CIGQWDRKDI 470 KKGEKNTIVT 480 SYNRNFTGRN 490 DANPETHAFV 500 TSPEIVTALA 510 IAGTLKFNPE 520 TDFLTGKDGK 530 KFKLEAPDAD 540 ELPRSDFDPG 550 QDTYQHPPKD 560 SSGQRVDVSP 570 TSQRLQLLEP 580 FDKWDGKDLE 590 DLQILIKVKG 600 KCTTDHISAA 610 GPWLKFRGHL 620 DNISNNLLIG 630 AINIENGKAN 640 SVRNAVTQEF 650 GPVPDTARYY 660 KKHGIRWVVI 670 GDENYGEGSS 680 REHAALEPRH 690 LGGRAIITKS 700 FARIHETNLK 710 KQGLLPLTFA 720 DPSDYNKIHP 730 VDKLTIQGLK 740 DFAPGKPLKC 750 VIKHPNGTQE 760 TILLNHTFNE 770 TQIEWFRAGS 780 ALNRMKELQQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005829 cytosol
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0043209 myelin sheath
Molecular Function GO:0051538 3 iron, 4 sulfur cluster binding
Molecular Function GO:0051539 4 iron, 4 sulfur cluster binding
Molecular Function GO:0003994 aconitate hydratase activity
Molecular Function GO:0005506 iron ion binding
Biological Process GO:0006101 citrate metabolic process
Biological Process GO:0006102 isocitrate metabolic process
Biological Process GO:0006099 tricarboxylic acid cycle

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.