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Overview

Uniprot IDQ99LB2
Protein NameDehydrogenase/reductase SDR family member 4
Gene NameDhrs4
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
106 KLITTALKRHQGIDI
159 AVVPEMEKRGGGSVV
217 CLAPGLIKTRFSSVL

Function

NADPH-dependent oxidoreductase which catalyzes the reduction of a variety of compounds bearing carbonyl groups including ketosteroids, alpha-dicarbonyl compounds, aldehydes, aromatic ketones and quinones. Reduces all-trans-retinal and 9-cis retinal. Reduces 3-ketosteroids and benzil into 3alpha-hydroxysteroids and S-benzoin, respectively, in contrast to the stereoselectivity of primates DHRS4s which produce 3beta-hydroxysteroids and R-benzoin. In the reverse reaction, catalyzes the NADP-dependent oxidation of 3alpha-hydroxysteroids and alcohol, but with much lower efficiency. Involved in the metabolism of 3alpha-hydroxysteroids, retinoid, isatin and xenobiotic carbonyl compounds

Protein Sequence

10 MQKAGRLLGG 20 WTQAWMSVRM 30 ASSGLTRRNP 40 LSNKVALVTA 50 STDGIGFAIA 60 RRLAEDGAHV 70 VVSSRKQQNV 80 DRAVATLQGE 90 GLSVTGIVCH 100 VGKAEDREKL 110 ITTALKRHQG 120 IDILVSNAAV 130 NPFFGNLMDV 140 TEEVWDKVLS 150 INVTATAMMI 160 KAVVPEMEKR 170 GGGSVVIVGS 180 VAGFTRFPSL 190 GPYNVSKTAL 200 LGLTKNFAAE 210 LAPKNIRVNC 220 LAPGLIKTRF 230 SSVLWEEKAR 240 EDFIKEAMQI 250 RRLGKPEDCA 260 GIVSFLCSED 270 ASYINGETVV VGGGTPSRL

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005778 peroxisomal membrane
Cellular Component GO:0005777 peroxisome
Molecular Function GO:0000253 3-beta-hydroxysteroid 3-dehydrogenase (NADP+) activity
Molecular Function GO:0018455 alcohol dehydrogenase [NAD(P)+] activity
Molecular Function GO:0052650 all-trans-retinol dehydrogenase (NADP+) activity
Molecular Function GO:0004090 carbonyl reductase (NADPH) activity
Molecular Function GO:0042802 identical protein binding
Molecular Function GO:0016655 oxidoreductase activity, acting on NAD(P)H, quinone or similar compound as acceptor
Molecular Function GO:0001758 retinal dehydrogenase (NAD+) activity
Biological Process GO:0042180 ketone metabolic process
Biological Process GO:0042574 retinal metabolic process
Biological Process GO:0008202 steroid metabolic process

Reference

[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.