Search Results
Overview
| Uniprot ID | Q99LB4 |
|---|---|
| Protein Name | Macrophage-capping protein |
| Gene Name | Capg |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 127 | GVESAFHKTTSGATP |
Function
Calcium-sensitive protein which reversibly blocks the barbed ends of actin filaments but does not sever preformed actin filaments. May play an important role in macrophage function. May play a role in regulating cytoplasmic and/or nuclear structures through potential interactions with actin. May bind DNA. Uncapping occurs either when Ca(2+) falls or when the concentration of polyphosphoinositide rises, both at low and high Ca(2+)
Protein Sequence
10
MYTPIPQSGS
20
PFPASVQDPG
30
LHIWRVEKLK
40
PVPIARESHG
50
IFFSGDSYLV
60
LHNGPEEASH
70
LHLWIGQQSS
80
RDEQGACAVL
90
AVHLNTLLGE
100
RPVQHREVQG
110
NESDLFMSYF
120
PRGLKYREGG
130
VESAFHKTTS
140
GATPAAIRKL
150
YQVKGKKNIR
160
ATERALSWDS
170
FNTGDCFILD
180
LGQNIFAWCG
190
GKSNILERNK
200
ARDLALAIRD
210
SERQGKAQVE
220
IITDGEEPAE
230
MIQVLGPKPA
240
LKEGNPEEDI
250
TADQTNAQAA
260
ALYKVSDATG
270
QMNLTKVADS
280
SPFASELLIP
290
DDCFVLDNGL
300
CGKIYIWKGR
310
KANEKERQAA
320
LQVADGFISR
330
MRYSPNTQVE
340
ILPQGRESPI
FKQFFKNWK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005814 | centriole |
| Cellular Component | GO:0090543 | Flemming body |
| Cellular Component | GO:0030027 | lamellipodium |
| Cellular Component | GO:0042470 | melanosome |
| Cellular Component | GO:0072686 | mitotic spindle |
| Cellular Component | GO:0005730 | nucleolus |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0001726 | ruffle |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0019904 | protein domain specific binding |
| Biological Process | GO:0051693 | actin filament capping |
Reference
[1] Sung E, Sim H, Cho YC, Lee W, Bae JS et al.. Global Profiling of Lysine Acetylation and Lactylation in Kupffer Cells.. J Proteome Res 22(12):3683-3691. 2023 Dec 1. PMID: 37897433.