Search Results
Overview
| Uniprot ID | Q99LC3 |
|---|---|
| Protein Name | NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial |
| Gene Name | Ndufa10 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 122 | EKFYDDPKSNDGNSY |
| 181 | YNQGYIRKQCVDHYN |
| 338 | FRELPGRKYAPGYNA |
| 70 | DGNICSGKNKLAKEI |
| 75 | SGKNKLAKEIAQQLG |
Function
Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone
Protein Sequence
10
MALRLLRLVP
20
ASAPARGLAA
30
GAQRVGRIHT
40
SVHCKLRYGL
50
LAAILGDKTT
60
KKLHEYSRVI
70
TVDGNICSGK
80
NKLAKEIAQQ
90
LGMKHYPEAG
100
IQYSSTTTGD
110
GRPLDIEFSG
120
SCSLEKFYDD
130
PKSNDGNSYR
140
LQSWLYASRL
150
LQYADALEHL
160
LSTGQGVVLE
170
RSIYSDFVFL
180
EAMYNQGYIR
190
KQCVDHYNEI
200
KRLTLPEYLP
210
PHAVIYIDVP
220
VPEVQSRIQK
230
KGDPHEMKVT
240
SAYLQDIENA
250
YKKTFLPKMS
260
EMCEVLVYDS
270
WEAEDPTKVV
280
EDIEYLKYNK
290
GPWLKQDDWT
300
FHYLRMLVQD
310
KTEVLNYTTI
320
PVYLPEITIG
330
AHQGSRIYNS
340
FRELPGRKYA
350
PGYNAEVGDK
WIWLK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005743 | mitochondrial inner membrane |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0043209 | myelin sheath |
| Cellular Component | GO:0045271 | respiratory chain complex I |
| Molecular Function | GO:0008137 | NADH dehydrogenase (ubiquinone) activity |
| Biological Process | GO:0009060 | aerobic respiration |
| Biological Process | GO:0006120 | mitochondrial electron transport, NADH to ubiquinone |
| Biological Process | GO:0042776 | proton motive force-driven mitochondrial ATP synthesis |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.