Search Results

Overview

Uniprot IDQ99LC5
Protein NameElectron transfer flavoprotein subunit alpha, mitochondrial
Gene NameEtfa
OrganismMus musculus

Kla Sites from experimental identification

Position Flanking peptide
158 GNALCTVKCDEKVKV
164 VKCDEKVKVFSVRGT
206 WLDQKLTKSDRPELT
216 RPELTGAKVVVSGGR
226 VSGGRGLKSGENFKL
294 LAGMKDSKTIVAINK
331 PEMTEILKKK*****
59 SCLVAGTKCDKVVQD
62 VAGTKCDKVVQDLCK
69 KVVQDLCKVAGVAKV
75 CKVAGVAKVLVAQHD

Function

Heterodimeric electron transfer flavoprotein that accepts electrons from several mitochondrial dehydrogenases, including acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). Required for normal mitochondrial fatty acid oxidation and normal amino acid metabolism

Protein Sequence

10 MFRAAAPGQL 20 RRAASLLRFQ 30 STLVIAEHAN 40 DSLAPITLNT 50 ITAAGRLGGE 60 VSCLVAGTKC 70 DKVVQDLCKV 80 AGVAKVLVAQ 90 HDAYKGLLPE 100 ELTPLILETQ 110 KQFSYTHICA 120 GASAFGKNLL 130 PRVAAKLNVA 140 PVSDIIEIKS 150 PDTFVRTIYA 160 GNALCTVKCD 170 EKVKVFSVRG 180 TSFEAAATSG 190 GSASSEKAPS 200 SSSVGISEWL 210 DQKLTKSDRP 220 ELTGAKVVVS 230 GGRGLKSGEN 240 FKLLYDLADQ 250 LHAAVGASRA 260 AVDAGFVPND 270 MQVGQTGKIV 280 APELYIAVGI 290 SGAIQHLAGM 300 KDSKTIVAIN 310 KDPEAPIFQV 320 ADYGIVADLF 330 KVVPEMTEIL KKK

Gene Ontology

Classification GO ID Description
Cellular Component GO:0045251 electron transfer flavoprotein complex
Cellular Component GO:0017133 mitochondrial electron transfer flavoprotein complex
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Molecular Function GO:0009055 electron transfer activity
Molecular Function GO:0050660 flavin adenine dinucleotide binding
Molecular Function GO:0016491 oxidoreductase activity
Biological Process GO:0009063 amino acid catabolic process
Biological Process GO:0033539 fatty acid beta-oxidation using acyl-CoA dehydrogenase
Biological Process GO:0022904 respiratory electron transport chain

Reference

[1] Chang J, Wu W, Qian P, Lu Z, He X et al.. Multi-omics study on the effect of moderate-intensity exercise on protein lactylation in mouse muscle tissue.. Front Cell Dev Biol 12:1472338. 2024. PMID: 39935788.

[2] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.

[3] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.