Search Results
Overview
| Uniprot ID | Q99LP6 |
|---|---|
| Protein Name | GrpE protein homolog 1, mitochondrial |
| Gene Name | Grpel1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 157 | QIQKVFTKHGLLRLD |
| 215 | PALVGVVKDA***** |
| 66 | TLLEEKAKLEEQLRE |
| 94 | NLRQRSQKLVEEAKL |
Function
Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of mitochondrial HSP70 to substrate proteins (By similarity)
Protein Sequence
10
MAARCVRLAR
20
RSLPALALSF
30
RPSPRLLCTA
40
TKQKNNGQNL
50
DEDLGHCEPK
60
TDPPSADKTL
70
LEEKAKLEEQ
80
LRETMEKYKR
90
ALADTENLRQ
100
RSQKLVEEAK
110
LYGIQGFCKD
120
LLEVADILEK
130
ATQSVPKEEI
140
SNNNPHLKSL
150
YEGLVMTEVQ
160
IQKVFTKHGL
170
LRLDPIGAKF
180
DPYEHEALFH
190
TPVEGKEPGT
200
VALVSKVGYK
210
LHGRTLRPAL
VGVVKDA
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0001405 | PAM complex, Tim23 associated import motor |
| Molecular Function | GO:0000774 | adenyl-nucleotide exchange factor activity |
| Molecular Function | GO:0001671 | ATPase activator activity |
| Molecular Function | GO:0051117 | ATPase binding |
| Molecular Function | GO:0042802 | identical protein binding |
| Molecular Function | GO:0042803 | protein homodimerization activity |
| Molecular Function | GO:0051087 | protein-folding chaperone binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0030150 | protein import into mitochondrial matrix |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.
[2] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.