Search Results
Overview
| Uniprot ID | Q99M87 |
|---|---|
| Protein Name | DnaJ homolog subfamily A member 3, mitochondrial |
| Gene Name | Dnaja3 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 130 | DTNKDDPKAKEKFSQ |
| 335 | FVTFRVQKSPVFRRD |
Function
Modulates apoptotic signal transduction or effector structures within the mitochondrial matrix. Affect cytochrome C release from the mitochondria and caspase 3 activation, but not caspase 8 activation. Isoform 1 increases apoptosis triggered by both TNF and the DNA-damaging agent mytomycin C; in sharp contrast, isoform 2 suppresses apoptosis. Can modulate IFN-gamma-mediated transcriptional activity (By similarity). Isoform 2 may play a role in neuromuscular junction development as an effector of the MUSK signaling pathway
Protein Sequence
10
MAAWCSPRWL
20
RVAVGTPRLP
30
AAAGRGVQQP
40
QGGVVATSLC
50
RKLCVSAFGL
60
SMGAHGPRAL
70
LTLRPGVRLT
80
GTKSFPFVCT
90
TSFHTSASLA
100
KDDYYQILGV
110
PRNASQKDIK
120
KAYYQLAKKY
130
HPDTNKDDPK
140
AKEKFSQLAE
150
AYEVLSDEVK
160
RKQYDAYGSA
170
GFDPGTSSSG
180
QGYWRGGPSV
190
DPEELFRKIF
200
GEFSSSPFGD
210
FQNVFDQPQE
220
YIMELTFNQA
230
AKGVNKEFTV
240
NIMDTCERCD
250
GKGNEPGTKV
260
QHCHYCGGSG
270
METINTGPFV
280
MRSTCRRCGG
290
RGSIITNPCV
300
VCRGAGQAKQ
310
KKRVTIPVPA
320
GVEDGQTVRM
330
PVGKREIFVT
340
FRVQKSPVFR
350
RDGADIHSDL
360
FISIAQAILG
370
GTAKAQGLYE
380
TINVTIPAGI
390
QTDQKIRLTG
400
KGIPRINSYG
410
YGDHYIHIKI
420
RVPKRLSSRQ
430
QNLILSYAED
440
ETDVEGTVNG
450
VTHTSTGGRT
460
MDSSAGSKDR
470
REAGEDNEGF
480
LSKLKKIFTS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005884 | actin filament |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0009898 | cytoplasmic side of plasma membrane |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0031594 | neuromuscular junction |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0005886 | plasma membrane |
| Cellular Component | GO:0045211 | postsynaptic membrane |
| Molecular Function | GO:0005524 | ATP binding |
| Molecular Function | GO:0140297 | DNA-binding transcription factor binding |
| Molecular Function | GO:0030695 | GTPase regulator activity |
| Molecular Function | GO:0030544 | Hsp70 protein binding |
| Molecular Function | GO:0106137 | IkappaB kinase complex binding |
| Molecular Function | GO:0051059 | NF-kappaB binding |
| Molecular Function | GO:0019901 | protein kinase binding |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0030971 | receptor tyrosine kinase binding |
| Molecular Function | GO:0061629 | RNA polymerase II-specific DNA-binding transcription factor binding |
| Molecular Function | GO:0005133 | type II interferon receptor binding |
| Molecular Function | GO:0051082 | unfolded protein binding |
| Molecular Function | GO:0008270 | zinc ion binding |
| Biological Process | GO:0006924 | activation-induced cell death of T cells |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0090398 | cellular senescence |
| Biological Process | GO:0006264 | mitochondrial DNA replication |
| Biological Process | GO:0007005 | mitochondrion organization |
| Biological Process | GO:0043066 | negative regulation of apoptotic process |
| Biological Process | GO:0043124 | negative regulation of canonical NF-kappaB signal transduction |
| Biological Process | GO:0008285 | negative regulation of cell population proliferation |
| Biological Process | GO:0043069 | negative regulation of programmed cell death |
| Biological Process | GO:0000122 | negative regulation of transcription by RNA polymerase II |
| Biological Process | GO:0060336 | negative regulation of type II interferon-mediated signaling pathway |
| Biological Process | GO:0007528 | neuromuscular junction development |
| Biological Process | GO:0043065 | positive regulation of apoptotic process |
| Biological Process | GO:0031398 | positive regulation of protein ubiquitination |
| Biological Process | GO:0042102 | positive regulation of T cell proliferation |
| Biological Process | GO:0006457 | protein folding |
| Biological Process | GO:0050821 | protein stabilization |
| Biological Process | GO:0009408 | response to heat |
| Biological Process | GO:0034341 | response to type II interferon |
| Biological Process | GO:0071340 | skeletal muscle acetylcholine-gated channel clustering |
| Biological Process | GO:0007264 | small GTPase-mediated signal transduction |
| Biological Process | GO:0033077 | T cell differentiation in thymus |
Reference
[1] Zhuo W, Zhang M, Tan J, Gao Y, Wang Y et al.. Lysine lactylation analysis of proteins in the heart of the Kawasaki disease mouse model.. Front Cell Dev Biol 13:1550220. 2025. PMID: 40114965.