Search Results
Overview
| Uniprot ID | Q99MI1 |
|---|---|
| Protein Name | ELKS/Rab6-interacting/CAST family member 1 |
| Gene Name | Erc1 |
| Organism | Mus musculus |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 10 | GSARSVGKVEPSSQS |
Function
Regulatory subunit of the IKK complex. Probably recruits IkappaBalpha/NFKBIA to the complex (By similarity). May be involved in the organization of the cytomatrix at the nerve terminals active zone (CAZ) which regulates neurotransmitter release. May be involved in vesicle trafficking at the CAZ. May be involved in Rab-6 regulated endosomes to Golgi transport
Protein Sequence
10
MYGSARSVGK
20
VEPSSQSPGR
30
SPRLPRSPRL
40
GHRRTNSTGG
50
SSGNSVGGGS
60
GKTLSMENIQ
70
SLNAAYATSG
80
PMYLSDHENV
90
GAETPKSTMT
100
LGRSGGRLPY
110
GVRMTAMGSS
120
PNIASSGVAS
130
DTIAFGEHHL
140
PPVSMASTVP
150
HSLRQARDNT
160
IMDLQTQLKE
170
VLRENDLLRK
180
DVEVKESKLS
190
SSMNSIKTFW
200
SPELKKERAL
210
RKDEASKITI
220
WKEQYRVVQE
230
ENQHMQMTIQ
240
ALQDELRIQR
250
DLNQLFQQDS
260
SSRTGEPCVA
270
ELTEENFQRL
280
HAEHERQAKE
290
LFLLRKTLEE
300
MELRIETQKQ
310
TLNARDESIK
320
KLLEMLQSKG
330
LSAKATEEDH
340
ERTRRLAEAE
350
MHVHHLESLL
360
EQKEKENNML
370
REEMHRRFEN
380
APDSAKTKAL
390
QTVIEMKDSK
400
ISSMERGLRD
410
LEEEIQMLKS
420
NGALSSEERE
430
EEMKQMEVYR
440
SHSKFMKNKV
450
EQLKEELSSK
460
DAQGEELKKR
470
AAGLQSEIGQ
480
VKQELSRKDT
490
ELLALQTKLE
500
TLTNQFSDSK
510
QHIEVLKESL
520
TAKEQRAAIL
530
QTEVDALRLR
540
LEEKETMLNK
550
KTKQIQDMAE
560
EKGTQAGEIH
570
DLKDMLDVKE
580
RKVNVLQKKI
590
ENLQEQLRDK
600
EKQMSSLKER
610
VKSLQADTTN
620
TDTALTTLEE
630
ALADKERTIE
640
RLKEQRDRDE
650
REKQEEIDTY
660
KKDLKDLREK
670
VSLLQGDLSE
680
KEASLLDIKE
690
HASSLASSGL
700
KKDSRLKTLE
710
IALEQKKEEC
720
LKMESQLKKA
730
HEATLEARAS
740
PEMSDRIQQL
750
EREISRYKDE
760
SSKAQTEVDR
770
LLEILKEVEN
780
EKNDKDKKIA
790
ELESLTSRQV
800
KDQNKKVANL
810
KHKEQVEKKK
820
SAQMLEEARR
830
REDSLSDSSQ
840
QLQDSLRKKD
850
DRIEELEEAL
860
RESVQITAER
870
EMVLAQEESA
880
RTNAEKQVEE
890
LLMAMEKVKQ
900
ELESMKAKLS
910
STQQSLAEKE
920
THLTNLRAER
930
RKHLEEVLEM
940
KQEALLAAIS
950
EKDANIALLE
960
LSSSKKKTQE
970
EVAALKREKD
980
RLVQQLKQQT
990
QNRMKLMADN
1000
YEDDHFRSSR
1010
SNQTNHKPSP
1020
DQIIQPLLEL
1030
DQNRSKLKLY
1040
IGHLTALCHD
1050
RDPLILRGLT
1060
PPASYNADGE
1070
QAAWENELQQ
1080
MTQEQLQNEL
1090
EKVEGDNAEL
1100
QEFANTILQQ
1110
IADHCPDILE
1120
QVVNALEESS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0036064 | ciliary basal body |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0098982 | GABA-ergic synapse |
| Cellular Component | GO:0098978 | glutamatergic synapse |
| Cellular Component | GO:0000139 | Golgi membrane |
| Cellular Component | GO:0008385 | IkappaB kinase complex |
| Cellular Component | GO:0016020 | membrane |
| Cellular Component | GO:0002102 | podosome |
| Cellular Component | GO:0014069 | postsynaptic density |
| Cellular Component | GO:0098831 | presynaptic active zone cytoplasmic component |
| Cellular Component | GO:0099523 | presynaptic cytosol |
| Cellular Component | GO:0045202 | synapse |
| Cellular Component | GO:0008021 | synaptic vesicle |
| Molecular Function | GO:0030165 | PDZ domain binding |
| Molecular Function | GO:0031267 | small GTPase binding |
| Molecular Function | GO:0098882 | structural constituent of presynaptic active zone |
| Biological Process | GO:0007252 | I-kappaB phosphorylation |
| Biological Process | GO:0048790 | maintenance of presynaptic active zone structure |
| Biological Process | GO:0015031 | protein transport |
| Biological Process | GO:0150037 | regulation of calcium-dependent activation of synaptic vesicle fusion |
| Biological Process | GO:0006355 | regulation of DNA-templated transcription |
| Biological Process | GO:0099509 | regulation of presynaptic cytosolic calcium ion concentration |
| Biological Process | GO:0042147 | retrograde transport, endosome to Golgi |
| Biological Process | GO:0016082 | synaptic vesicle priming |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.