Overview
| Uniprot ID | Q99PT1 |
|---|
| Protein Name | Rho GDP-dissociation inhibitor 1 |
|---|
| Gene Name | Arhgdia |
|---|
| Organism | Mus musculus |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 43 |
QEIQELDKDDESLRK |
Function
Controls Rho proteins homeostasis. Regulates the GDP/GTP exchange reaction of the Rho proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP to them. Retains Rho proteins such as CDC42, RAC1 and RHOA in an inactive cytosolic pool, regulating their stability and protecting them from degradation. Actively involved in the recycling and distribution of activated Rho GTPases in the cell, mediates extraction from membranes of both inactive and activated molecules due its exceptionally high affinity for prenylated forms. Through the modulation of Rho proteins, may play a role in cell motility regulation. In glioma cells, inhibits cell migration and invasion by mediating the signals of SEMA5A and PLXNB3 that lead to inactivation of RAC1
Protein Sequence
10
MAEQEPTAEQ
20
LAQIAAENEE
30
DEHSVNYKPP
40
AQKSIQEIQE
50
LDKDDESLRK
60
YKEALLGRVA
70
VSADPNVPNV
80
IVTRLTLVCS
90
TAPGPLELDL
100
TGDLESFKKQ
110
SFVLKEGVEY
120
RIKISFRVNR
130
EIVSGMKYIQ
140
HTYRKGVKID
150
KTDYMVGSYG
160
PRAEEYEFLT
170
PMEEAPKGML
180
ARGSYNIKSR
190
FTDDDKTDHL
200
SWEWNLTIKK
EWKD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005615 |
extracellular space |
| Cellular Component |
GO:0001772 |
immunological synapse |
| Cellular Component |
GO:0016020 |
membrane |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:0098685 |
Schaffer collateral - CA1 synapse |
| Cellular Component |
GO:0045202 |
synapse |
| Molecular Function |
GO:0005504 |
fatty acid binding |
| Molecular Function |
GO:0005096 |
GTPase activator activity |
| Molecular Function |
GO:0051879 |
Hsp90 protein binding |
| Molecular Function |
GO:0019901 |
protein kinase binding |
| Molecular Function |
GO:0005094 |
Rho GDP-dissociation inhibitor activity |
| Molecular Function |
GO:0031267 |
small GTPase binding |
| Biological Process |
GO:0071260 |
cellular response to mechanical stimulus |
| Biological Process |
GO:0030336 |
negative regulation of cell migration |
| Biological Process |
GO:0008360 |
regulation of cell shape |
| Biological Process |
GO:0032880 |
regulation of protein localization |
| Biological Process |
GO:0035023 |
regulation of Rho protein signal transduction |
| Biological Process |
GO:0098693 |
regulation of synaptic vesicle cycle |
| Biological Process |
GO:0007266 |
Rho protein signal transduction |
| Biological Process |
GO:0071526 |
semaphorin-plexin signaling pathway |
Reference
[1] Wu D, Tang Y, Li X, Xiong S, Zhang Z et al.. Characterization of protein lactylation in healthy and ischemic mouse hearts.. Front Cardiovasc Med 12:1644886. 2025. PMID: 41089239.