Search Results

Overview

Uniprot IDQ9BPW8
Protein NameProtein NipSnap homolog 1
Gene NameNIPSNAP1
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
146 MNKLKNNKEYLEFRR
191 IYELRTYKLKPGTMI
193 ELRTYKLKPGTMIEW
279 SRIMIPLKISPLQ**
51 FRSLFVHKVDPRKDA
56 VHKVDPRKDAHSTLL
65 AHSTLLSKKETSNLY
66 HSTLLSKKETSNLYK
73 KETSNLYKIQFHNVK

Function

Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (PubMed:30982665)

Protein Sequence

10 MAPRLCSISV 20 TARRLLGGPG 30 PRAGDVASAA 40 AARFYSKDNE 50 GSWFRSLFVH 60 KVDPRKDAHS 70 TLLSKKETSN 80 LYKIQFHNVK 90 PEYLDAYNSL 100 TEAVLPKLHL 110 DEDYPCSLVG 120 NWNTWYGEQD 130 QAVHLWRFSG 140 GYPALMDCMN 150 KLKNNKEYLE 160 FRRERSQMLL 170 SRRNQLLLEF 180 SFWNEPQPRM 190 GPNIYELRTY 200 KLKPGTMIEW 210 GNNWARAIKY 220 RQENQEAVGG 230 FFSQIGELYV 240 VHHLWAYKDL 250 QSREETRNAA 260 WRKRGWDENV 270 YYTVPLVRHM 280 ESRIMIPLKI SPLQ

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005759 mitochondrial matrix
Cellular Component GO:0005739 mitochondrion
Cellular Component GO:0097060 synaptic membrane
Molecular Function GO:0030674 protein-macromolecule adaptor activity
Biological Process GO:0000423 mitophagy
Biological Process GO:0019233 sensory perception of pain

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] Shi CM, Wang QC, Li XL, Yang YH, Tang XY et al.. Global Profiling of Protein Lactylation in Human Hippocampi.. Proteomics Clin Appl 19(2):e202400061. 2025 Mar. PMID: 39610256.