Search Results
Overview
| Uniprot ID | Q9BPW9 |
|---|---|
| Protein Name | Dehydrogenase/reductase SDR family member 9 |
| Gene Name | DHRS9 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 30 | KIEDITDKYIFITGC |
Function
3-alpha-hydroxysteroid dehydrogenase that converts 3-alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone (PubMed:11294878, PubMed:29541409). Also plays a role in the biosynthesis of retinoic acid from retinaldehyde (PubMed:11304534, PubMed:12618084). Can utilize both NADH and NADPH
Protein Sequence
10
MLFWVLGLLI
20
LCGFLWTRKG
30
KLKIEDITDK
40
YIFITGCDSG
50
FGNLAARTFD
60
KKGFHVIAAC
70
LTESGSTALK
80
AETSERLRTV
90
LLDVTDPENV
100
KRTAQWVKNQ
110
VGEKGLWGLI
120
NNAGVPGVLA
130
PTDWLTLEDY
140
REPIEVNLFG
150
LISVTLNMLP
160
LVKKAQGRVI
170
NVSSVGGRLA
180
IVGGGYTPSK
190
YAVEGFNDSL
200
RRDMKAFGVH
210
VSCIEPGLFK
220
TNLADPVKVI
230
EKKLAIWEQL
240
SPDIKQQYGE
250
GYIEKSLDKL
260
KGNKSYVNMD
270
LSPVVECMDH
280
ALTSLFPKTH
290
YAAGKDAKIF
300
WIPLSHMPAA
310
LQDFLLLKQK
AELANPKAV
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005789 | endoplasmic reticulum membrane |
| Molecular Function | GO:0004022 | alcohol dehydrogenase (NAD+) activity |
| Molecular Function | GO:0004745 | all-trans-retinol dehydrogenase (NAD+) activity |
| Molecular Function | GO:0047044 | androstan-3-alpha,17-beta-diol dehydrogenase (NAD+) activity |
| Molecular Function | GO:0047023 | androsterone dehydrogenase [NAD(P)+] activity |
| Molecular Function | GO:0016491 | oxidoreductase activity |
| Molecular Function | GO:0016854 | racemase and epimerase activity |
| Molecular Function | GO:0047035 | testosterone dehydrogenase (NAD+) activity |
| Biological Process | GO:0042904 | 9-cis-retinoic acid biosynthetic process |
| Biological Process | GO:0008209 | androgen metabolic process |
| Biological Process | GO:0030855 | epithelial cell differentiation |
| Biological Process | GO:0042448 | progesterone metabolic process |
| Biological Process | GO:0042572 | retinol metabolic process |
| Biological Process | GO:0008202 | steroid metabolic process |
Reference
PMID: N/A