Search Results

Overview

Uniprot IDQ9BPX3
Protein NameCondensin complex subunit 3
Gene NameNCAPG
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1003 TAALEKSKLNLAQFL
943 VKATQASKSTQLKTN
955 KTNRGQRKVTVSART
995 MRLPRRAKTAALEKS

Function

Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases

Protein Sequence

10 MGAERRLLSI 20 KEAFRLAQQP 30 HQNQAKLVVA 40 LSRTYRTMDD 50 KTVFHEEFIH 60 YLKYVMVVYK 70 REPAVERVIE 80 FAAKFVTSFH 90 QSDMEDDEEE 100 EDGGLLNYLF 110 TFLLKSHEAN 120 SNAVRFRVCL 130 LINKLLGSMP 140 ENAQIDDDVF 150 DKINKAMLIR 160 LKDKIPNVRI 170 QAVLALSRLQ 180 DPKDDECPVV 190 NAYATLIEND 200 SNPEVRRAVL 210 SCIAPSAKTL 220 PKIVGRTKDV 230 KEAVRKLAYQ 240 VLAEKVHMRA 250 MSIAQRVMLL 260 QQGLNDRSDA 270 VKQAMQKHLL 280 QGWLRFSEGN 290 ILELLHRLDV 300 ENSSEVAVSV 310 LNALFSITPL 320 SELVGLCKNN 330 DGRKLIPVET 340 LTPEIALYWC 350 ALCEYLKSKG 360 DEGEEFLEQI 370 LPEPVVYADY 380 LLSYIQSIPV 390 VNEEHRGDFS 400 YIGNLMTKEF 410 IGQQLILIIK 420 SLDTSEEGGR 430 KKLLAVLQEI 440 LILPTIPISL 450 VSFLVERLLH 460 IIIDDNKRTQ 470 IVTEIISEIR 480 APIVTVGVNN 490 DPADVRKKEL 500 KMAEIKVKLI 510 EAKEALENCI 520 TLQDFNRASE 530 LKEEIKALED 540 ARINLLKETE 550 QLEIKEVHIE 560 KNDAETLQKC 570 LILCYELLKQ 580 MSISTGLSAT 590 MNGIIESLIL 600 PGIISIHPVV 610 RNLAVLCLGC 620 CGLQNQDFAR 630 KHFVLLLQVL 640 QIDDVTIKIS 650 ALKAIFDQLM 660 TFGIEPFKTK 670 KIKTLHCEGT 680 EINSDDEQES 690 KEVEETATAK 700 NVLKLLSDFL 710 DSEVSELRTG 720 AAEGLAKLMF 730 SGLLVSSRIL 740 SRLILLWYNP 750 VTEEDVQLRH 760 CLGVFFPVFA 770 YASRTNQECF 780 EEAFLPTLQT 790 LANAPASSPL 800 AEIDITNVAE 810 LLVDLTRPSG 820 LNPQAKTSQD 830 YQALTVHDNL 840 AMKICNEILT 850 SPCSPEIRVY 860 TKALSSLELS 870 SHLAKDLLVL 880 LNEILEQVKD 890 RTCLRALEKI 900 KIQLEKGNKE 910 FGDQAEAAQD 920 ATLTTTTFQN 930 EDEKNKEVYM 940 TPLRGVKATQ 950 ASKSTQLKTN 960 RGQRKVTVSA 970 RTNRRCQTAE 980 ADSESDHEVP 990 EPESEMKMRL 1000 PRRAKTAALE 1010 KSKLNLAQFL NEDLS

Gene Ontology

Classification GO ID Description
Cellular Component GO:0000793 condensed chromosome
Cellular Component GO:0000779 condensed chromosome, centromeric region
Cellular Component GO:0000794 condensed nuclear chromosome
Cellular Component GO:0000796 condensin complex
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0016020 membrane
Cellular Component GO:0005634 nucleus
Biological Process GO:0051301 cell division
Biological Process GO:0007076 mitotic chromosome condensation
Biological Process GO:1905821 positive regulation of chromosome condensation
Biological Process GO:0051984 positive regulation of chromosome segregation
Biological Process GO:1905820 positive regulation of chromosome separation

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.