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Overview

Uniprot IDQ9BQ39
Protein NameATP-dependent RNA helicase DDX50
Gene NameDDX50
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
207 QRNQETIKKSRSPKV
87 RLSDEFSKSHKSRRK
94 KSHKSRRKDLPNGDI

Function

ATP-dependent RNA helicase that may play a role in various aspects of RNA metabolism including pre-mRNA splicing or ribosomal RNA production (PubMed:12027455). Also acts as a viral restriction factor and promotes the activation of the NF-kappa-B and IRF3 signaling pathways following its stimulation with viral RNA or infection with RNA and DNA viruses (PubMed:35215908). For instance, decreases vaccinia virus, herpes simplex virus, Zika virus or dengue virus replication during the early stage of infection (PubMed:28181036, PubMed:35215908). Mechanistically, acts via the adapter TICAM1 and independently of the DDX1-DDX21-DHX36 helicase complex to induce the production of interferon-beta (PubMed:35215908)

Protein Sequence

10 MPGKLLWGDI 20 MELEAPLEES 30 ESQKKERQKS 40 DRRKSRHHYD 50 SDEKSETREN 60 GVTDDLDAPK 70 AKKSKMKEKL 80 NGDTEEGFNR 90 LSDEFSKSHK 100 SRRKDLPNGD 110 IDEYEKKSKR 120 VSSLDTSTHK 130 SSDNKLEETL 140 TREQKEGAFS 150 NFPISEETIK 160 LLKGRGVTYL 170 FPIQVKTFGP 180 VYEGKDLIAQ 190 ARTGTGKTFS 200 FAIPLIERLQ 210 RNQETIKKSR 220 SPKVLVLAPT 230 RELANQVAKD 240 FKDITRKLSV 250 ACFYGGTSYQ 260 SQINHIRNGI 270 DILVGTPGRI 280 KDHLQSGRLD 290 LSKLRHVVLD 300 EVDQMLDLGF 310 AEQVEDIIHE 320 SYKTDSEDNP 330 QTLLFSATCP 340 QWVYKVAKKY 350 MKSRYEQVDL 360 VGKMTQKAAT 370 TVEHLAIQCH 380 WSQRPAVIGD 390 VLQVYSGSEG 400 RAIIFCETKK 410 NVTEMAMNPH 420 IKQNAQCLHG 430 DIAQSQREIT 440 LKGFREGSFK 450 VLVATNVAAR 460 GLDIPEVDLV 470 IQSSPPQDVE 480 SYIHRSGRTG 490 RAGRTGICIC 500 FYQPRERGQL 510 RYVEQKAGIT 520 FKRVGVPSTM 530 DLVKSKSMDA 540 IRSLASVSYA 550 AVDFFRPSAQ 560 RLIEEKGAVD 570 ALAAALAHIS 580 GASSFEPRSL 590 ITSDKGFVTM 600 TLESLEEIQD 610 VSCAWKELNR 620 KLSSNAVSQI 630 TRMCLLKGNM 640 GVCFDVPTTE 650 SERLQAEWHD 660 SDWILSVPAK 670 LPEIEEYYDG 680 NTSSNSRQRS 690 GWSSGRSGRS 700 GRSGGRSGGR 710 SGRQSRQGSR 720 SGSRQDGRRR 730 SGNRNRSRSG GHKRSFD

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0016020 membrane
Cellular Component GO:0005730 nucleolus
Molecular Function GO:0005524 ATP binding
Molecular Function GO:0016887 ATP hydrolysis activity
Molecular Function GO:0003729 mRNA binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0003724 RNA helicase activity

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[3] Chao L, Xu Y, Yang Y, Ao X, Liang J. Identification of lactylation-related biomarkers for diagnosis, prognosis, and treatment responsiveness in triple-negative breast cancer.. World J Surg Oncol 24(1):77. 2026 Jan 22. PMID: 41566505.