Search Results
Overview
| Uniprot ID | Q9BQ52 |
|---|---|
| Protein Name | Zinc phosphodiesterase ELAC protein 2 |
| Gene Name | ELAC2 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 821 | HTEEPQAKKVRAQ** |
| 822 | TEEPQAKKVRAQ*** |
Function
Zinc phosphodiesterase, which displays mitochondrial tRNA 3'-processing endonuclease activity. Involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA (PubMed:21593607). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly (PubMed:24703694)
Protein Sequence
10
MWALCSLLRS
20
AAGRTMSQGR
30
TISQAPARRE
40
RPRKDPLRHL
50
RTREKRGPSG
60
CSGGPNTVYL
70
QVVAAGSRDS
80
GAALYVFSEF
90
NRYLFNCGEG
100
VQRLMQEHKL
110
KVARLDNIFL
120
TRMHWSNVGG
130
LSGMILTLKE
140
TGLPKCVLSG
150
PPQLEKYLEA
160
IKIFSGPLKG
170
IELAVRPHSA
180
PEYEDETMTV
190
YQIPIHSEQR
200
RGKHQPWQSP
210
ERPLSRLSPE
220
RSSDSESNEN
230
EPHLPHGVSQ
240
RRGVRDSSLV
250
VAFICKLHLK
260
RGNFLVLKAK
270
EMGLPVGTAA
280
IAPIIAAVKD
290
GKSITHEGRE
300
ILAEELCTPP
310
DPGAAFVVVE
320
CPDESFIQPI
330
CENATFQRYQ
340
GKADAPVALV
350
VHMAPASVLV
360
DSRYQQWMER
370
FGPDTQHLVL
380
NENCASVHNL
390
RSHKIQTQLN
400
LIHPDIFPLL
410
TSFRCKKEGP
420
TLSVPMVQGE
430
CLLKYQLRPR
440
REWQRDAIIT
450
CNPEEFIVEA
460
LQLPNFQQSV
470
QEYRRSAQDG
480
PAPAEKRSQY
490
PEIIFLGTGS
500
AIPMKIRNVS
510
ATLVNISPDT
520
SLLLDCGEGT
530
FGQLCRHYGD
540
QVDRVLGTLA
550
AVFVSHLHAD
560
HHTGLPSILL
570
QRERALASLG
580
KPLHPLLVVA
590
PNQLKAWLQQ
600
YHNQCQEVLH
610
HISMIPAKCL
620
QEGAEISSPA
630
VERLISSLLR
640
TCDLEEFQTC
650
LVRHCKHAFG
660
CALVHTSGWK
670
VVYSGDTMPC
680
EALVRMGKDA
690
TLLIHEATLE
700
DGLEEEAVEK
710
THSTTSQAIS
720
VGMRMNAEFI
730
MLNHFSQRYA
740
KVPLFSPNFS
750
EKVGVAFDHM
760
KVCFGDFPTM
770
PKLIPPLKAL
780
FAGDIEEMEE
790
RREKRELRQV
800
RAALLSRELA
810
GGLEDGEPQQ
820
KRAHTEEPQA
KKVRAQ
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005759 | mitochondrial matrix |
| Cellular Component | GO:0042645 | mitochondrial nucleoid |
| Cellular Component | GO:0005739 | mitochondrion |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0005634 | nucleus |
| Molecular Function | GO:0042781 | 3'-tRNA processing endoribonuclease activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0003723 | RNA binding |
| Molecular Function | GO:0004521 | RNA endonuclease activity |
| Molecular Function | GO:0004549 | tRNA-specific ribonuclease activity |
| Biological Process | GO:1990180 | mitochondrial tRNA 3'-end processing |
| Biological Process | GO:0090646 | mitochondrial tRNA processing |
| Biological Process | GO:0042780 | tRNA 3'-end processing |
| Biological Process | GO:0016078 | tRNA decay |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.