Search Results

Overview

Uniprot IDQ9BQ61
Protein NameTelomerase RNA component-interacting RNase
Gene NameTRIR
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
104 AAGPGDPKRKGGPGS
106 GPGDPKRKGGPGSTL
118 STLSFVGKRRGGNKL
124 GKRRGGNKLALKTGI
128 GGNKLALKTGIVAKK
134 LKTGIVAKKQKTEDE
135 KTGIVAKKQKTEDEV
146 EDEVLTSKGDAWAKY
152 SKGDAWAKYMAEVKK
158 AKYMAEVKKYKAHQC
159 KYMAEVKKYKAHQCG
161 MAEVKKYKAHQCGDD
176 DKTRPLVK*******

Function

Exoribonuclease that is part of the telomerase RNA 3' end processing complex and which has the ability to cleave all four unpaired RNA nucleotides from the 5' end or 3' end with higher efficiency for purine bases (PubMed:28322335)

Protein Sequence

10 MAARGRRAEP 20 QGREAPGPAG 30 GGGGGSRWAE 40 SGSGTSPESG 50 DEEVSGAGSS 60 PVSGGVNLFA 70 NDGSFLELFK 80 RKMEEEQRQR 90 QEEPPPGPQR 100 PDQSAAAAGP 110 GDPKRKGGPG 120 STLSFVGKRR 130 GGNKLALKTG 140 IVAKKQKTED 150 EVLTSKGDAW 160 AKYMAEVKKY 170 KAHQCGDDDK TRPLVK

Gene Ontology

Classification GO ID Description
Molecular Function GO:0008408 3'-5' exonuclease activity
Molecular Function GO:0008409 5'-3' exonuclease activity
Molecular Function GO:0003723 RNA binding
Biological Process GO:0016075 rRNA catabolic process

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[3] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.

[4] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[5] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[6] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[7] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.