Overview
| Uniprot ID | Q9BQ70 |
|---|
| Protein Name | Ribosome quality control complex subunit TCF25 |
|---|
| Gene Name | TCF25 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 124 |
EQSHASGKLRKKKKK |
Function
Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation (PubMed:30244831). In the RQC complex, required to promote formation of 'Lys-48'-linked polyubiquitin chains during ubiquitination of incompletely synthesized proteins by LTN1 (PubMed:30244831). May negatively regulate the calcineurin-NFAT signaling cascade by suppressing the activity of transcription factor NFATC4 (By similarity). May play a role in cell death control (By similarity)
Protein Sequence
10
MSRRALRRLR
20
GEQRGQEPLG
30
PGALHFDLRD
40
DDDAEEEGPK
50
RELGVRRPGG
60
AGKEGVRVNN
70
RFELINIDDL
80
EDDPVVNGER
90
SGCALTDAVA
100
PGNKGRGQRG
110
NTESKTDGDD
120
TETVPSEQSH
130
ASGKLRKKKK
140
KQKNKKSSTG
150
EASENGLEDI
160
DRILERIEDS
170
TGLNRPGPAP
180
LSSRKHVLYV
190
EHRHLNPDTE
200
LKRYFGARAI
210
LGEQRPRQRQ
220
RVYPKCTWLT
230
TPKSTWPRYS
240
KPGLSMRLLE
250
SKKGLSFFAF
260
EHSEEYQQAQ
270
HKFLVAVESM
280
EPNNIVVLLQ
290
TSPYHVDSLL
300
QLSDACRFQE
310
DQEMARDLVE
320
RALYSMECAF
330
HPLFSLTSGA
340
CRLDYRRPEN
350
RSFYLALYKQ
360
MSFLEKRGCP
370
RTALEYCKLI
380
LSLEPDEDPL
390
CMLLLIDHLA
400
LRARNYEYLI
410
RLFQEWEAHR
420
NLSQLPNFAF
430
SVPLAYFLLS
440
QQTDLPECEQ
450
SSARQKASLL
460
IQQALTMFPG
470
VLLPLLESCS
480
VRPDASVSSH
490
RFFGPNAEIS
500
QPPALSQLVN
510
LYLGRSHFLW
520
KEPATMSWLE
530
ENVHEVLQAV
540
DAGDPAVEAC
550
ENRRKVLYQR
560
APRNIHRHVI
570
LSEIKEAVAA
580
LPPDVTTQSV
590
MGFDPLPPSD
600
TIYSYVRPER
610
LSPISHGNTI
620
ALFFRSLLPN
630
YTMEGERPEE
640
GVAGGLNRNQ
650
GLNRLMLAVR
660
DMMANFHLND
670
LEAPHEDDAE
GEGEWD
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005829 |
cytosol |
| Cellular Component |
GO:0005634 |
nucleus |
| Cellular Component |
GO:1990112 |
RQC complex |
| Biological Process |
GO:0006351 |
DNA-templated transcription |
| Biological Process |
GO:0061945 |
regulation of protein K48-linked ubiquitination |
| Biological Process |
GO:0072344 |
rescue of stalled cytosolic ribosome |
| Biological Process |
GO:1990116 |
ribosome-associated ubiquitin-dependent protein catabolic process |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.