Search Results
Overview
| Uniprot ID | Q9BQE3 |
|---|---|
| Protein Name | Tubulin alpha-1C chain |
| Gene Name | TUBA1C |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 326 | YRGDVVPKDVNAAIA |
| 336 | NAAIATIKTKRTIQF |
| 338 | AIATIKTKRTIQFVD |
| 401 | KFDLMYAKRAFVHWY |
Function
Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin
Protein Sequence
10
MRECISIHVG
20
QAGVQIGNAC
30
WELYCLEHGI
40
QPDGQMPSDK
50
TIGGGDDSFN
60
TFFSETGAGK
70
HVPRAVFVDL
80
EPTVIDEVRT
90
GTYRQLFHPE
100
QLITGKEDAA
110
NNYARGHYTI
120
GKEIIDLVLD
130
RIRKLADQCT
140
GLQGFLVFHS
150
FGGGTGSGFT
160
SLLMERLSVD
170
YGKKSKLEFS
180
IYPAPQVSTA
190
VVEPYNSILT
200
THTTLEHSDC
210
AFMVDNEAIY
220
DICRRNLDIE
230
RPTYTNLNRL
240
ISQIVSSITA
250
SLRFDGALNV
260
DLTEFQTNLV
270
PYPRIHFPLA
280
TYAPVISAEK
290
AYHEQLTVAE
300
ITNACFEPAN
310
QMVKCDPRHG
320
KYMACCLLYR
330
GDVVPKDVNA
340
AIATIKTKRT
350
IQFVDWCPTG
360
FKVGINYQPP
370
TVVPGGDLAK
380
VQRAVCMLSN
390
TTAVAEAWAR
400
LDHKFDLMYA
410
KRAFVHWYVG
420
EGMEEGEFSE
430
AREDMAALEK
440
DYEEVGADSA
DGEDEGEEY
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005929 | cilium |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005881 | cytoplasmic microtubule |
| Cellular Component | GO:0005874 | microtubule |
| Cellular Component | GO:0015630 | microtubule cytoskeleton |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0031982 | vesicle |
| Molecular Function | GO:0005525 | GTP binding |
| Molecular Function | GO:0016787 | hydrolase activity |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0005200 | structural constituent of cytoskeleton |
| Molecular Function | GO:0005198 | structural molecule activity |
| Biological Process | GO:0051301 | cell division |
| Biological Process | GO:0030705 | cytoskeleton-dependent intracellular transport |
| Biological Process | GO:0000226 | microtubule cytoskeleton organization |
| Biological Process | GO:0007017 | microtubule-based process |
| Biological Process | GO:0000278 | mitotic cell cycle |
| Biological Process | GO:0030182 | neuron differentiation |
Reference
[1] Lin Y, Chen M, Wang D, Yu Y, Chen R et al.. Multi-Proteomic Analysis Reveals the Effect of Protein Lactylation on Matrix and Cholesterol Metabolism in Tendinopathy.. J Proteome Res 22(6):1712-1722. 2023 Jun 2. PMID: 37159428.