Search Results
Overview
| Uniprot ID | Q9BQE9 |
|---|---|
| Protein Name | B-cell CLL/lymphoma 7 protein family member B |
| Gene Name | BCL7B |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 20 | RAKDDIKKVMAAIEK |
Function
Positive regulator of apoptosis. Plays a role in the Wnt signaling pathway, negatively regulating the expression of Wnt signaling components CTNNB1 and HMGA1 (PubMed:25569233). Involved in cell cycle progression, maintenance of the nuclear structure and stem cell differentiation (PubMed:25569233). May play a role in lung tumor development or progression (By similarity)
Protein Sequence
10
MSGRSVRAET
20
RSRAKDDIKK
30
VMAAIEKVRK
40
WEKKWVTVGD
50
TSLRIFKWVP
60
VTDSKEKEKS
70
KSNSSAAREP
80
NGFPSDASAN
90
SSLLLEFQDE
100
NSNQSSVSDV
110
YQLKVDSSTN
120
SSPSPQQSES
130
LSPAHTSDFR
140
TDDSQPPTLG
150
QEILEEPSLP
160
SSEVADEPPT
170
LTKEEPVPLE
180
TQVVEEEEDS
190
GAPPLKRFCV
200
DQPTVPQTAS
ES
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0000785 | chromatin |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0016514 | SWI/SNF complex |
| Molecular Function | GO:0003779 | actin binding |
| Biological Process | GO:0006915 | apoptotic process |
| Biological Process | GO:0030154 | cell differentiation |
| Biological Process | GO:0006338 | chromatin remodeling |
| Biological Process | GO:0045596 | negative regulation of cell differentiation |
| Biological Process | GO:0008284 | positive regulation of cell population proliferation |
| Biological Process | GO:2000781 | positive regulation of double-strand break repair |
| Biological Process | GO:1902459 | positive regulation of stem cell population maintenance |
| Biological Process | GO:0070316 | regulation of G0 to G1 transition |
| Biological Process | GO:2000045 | regulation of G1/S transition of mitotic cell cycle |
| Biological Process | GO:0030071 | regulation of mitotic metaphase/anaphase transition |
| Biological Process | GO:2000819 | regulation of nucleotide-excision repair |
| Biological Process | GO:0006357 | regulation of transcription by RNA polymerase II |
| Biological Process | GO:0016055 | Wnt signaling pathway |
Reference
[1] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.