Search Results

Overview

Uniprot IDQ9BQG0
Protein NameMyb-binding protein 1A
Gene NameMYBBP1A
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
1167 ATQSPISKKRKKKGF
1168 TQSPISKKRKKKGFL
1172 ISKKRKKKGFLPETK
1231 ANGTPTTKSPAPGAP
1247 RSPSTPAKSPKLQKK
1279 AGQKQHQKALPKKGV
1289 PKKGVLGKSPLSALA
1317 SLLQSGAKKKAQVRK
1318 LLQSGAKKKAQVRKA
432 FSTNNQKKAQDSSLH
489 HSFFVTKKPTSQIPE

Function

May activate or repress transcription via interactions with sequence specific DNA-binding proteins (By similarity). Repression may be mediated at least in part by histone deacetylase activity (HDAC activity) (By similarity). Acts as a corepressor and in concert with CRY1, represses the transcription of the core circadian clock component PER2 (By similarity). Preferentially binds to dimethylated histone H3 'Lys-9' (H3K9me2) on the PER2 promoter (By similarity). Has a role in rRNA biogenesis together with PWP1 (PubMed:29065309)

Protein Sequence

10 MESRDPAQPM 20 SPGEATQSGA 30 RPADRYGLLK 40 HSREFLDFFW 50 DIAKPEQETR 60 LAATEKLLEY 70 LRGRPKGSEM 80 KYALKRLITG 90 LGVGRETARP 100 CYSLALAQLL 110 QSFEDLPLCS 120 ILQQIQEKYD 130 LHQVKKAMLR 140 PALFANLFGV 150 LALFQSGRLV 160 KDQEALMKSV 170 KLLQALAQYQ 180 NHLQEQPRKA 190 LVDILSEVSK 200 ATLQEILPEV 210 LKADLNIILS 220 SPEQLELFLL 230 AQQKVPSKLK 240 KLVGSVNLFS 250 DENVPRLVNV 260 LKMAASSVKK 270 DRKLPAIALD 280 LLRLALKEDK 290 FPRFWKEVVE 300 QGLLKMQFWP 310 ASYLCFRLLG 320 AALPLLTKEQ 330 LHLVMQGDVI 340 RHYGEHVCTA 350 KLPKQFKFAP 360 EMDDYVGTFL 370 EGCQDDPERQ 380 LAVLVAFSSV 390 TNQGLPVTPT 400 FWRVVRFLSP 410 PALQGYVAWL 420 RAMFLQPDLD 430 SLVDFSTNNQ 440 KKAQDSSLHM 450 PERAVFRLRK 460 WIIFRLVSIV 470 DSLHLEMEEA 480 LTEQVARFCL 490 FHSFFVTKKP 500 TSQIPETKHP 510 FSFPLENQAR 520 EAVSSAFFSL 530 LQTLSTQFKQ 540 APGQTQGGQP 550 WTYHLVQFAD 560 LLLNHSHNVT 570 TVTPFTAQQR 580 QAWDRMLQTL 590 KELEAHSAEA 600 RAAAFQHLLL 610 LVGIHLLKSP 620 AESCDLLGDI 630 QTCIRKSLGE 640 KPRRSRTKTI 650 DPQEPPWVEV 660 LVEILLALLA 670 QPSHLMRQVA 680 RSVFGHICSH 690 LTPRALQLIL 700 DVLNPETSED 710 ENDRVVVTDD 720 SDERRLKGAE 730 DKSEEGEDNR 740 SSESEEESEG 750 EESEEEERDG 760 DVDQGFREQL 770 MTVLQAGKAL 780 GGEDSENEEE 790 LGDEAMMALD 800 QSLASLFAEQ 810 KLRIQARRDE 820 KNKLQKEKAL 830 RRDFQIRVLD 840 LVEVLVTKQP 850 ENALVLELLE 860 PLLSIIRRSL 870 RSSSSKQEQD 880 LLHKTARIFT 890 HHLCRARRYC 900 HDLGERAGAL 910 HAQVERLVQQ 920 AGRQPDSPTA 930 LYHFNASLYL 940 LRVLKGNTAE 950 GCVHETQEKQ 960 KAGTDPSHMP 970 TGPQAASCLD 980 LNLVTRVYST 990 ALSSFLTKRN 1000 SPLTVPMFLS 1010 LFSRHPVLCQ 1020 SLLPILVQHI 1030 TGPVRPRHQA 1040 CLLLQKTLSM 1050 REVRSCFEDP 1060 EWKQLMGQVL 1070 AKVTENLRVL 1080 GEAQTKAQHQ 1090 QALSSLELLN 1100 VLFRTCKHEK 1110 LTLDLTVLLG 1120 VLQGQQQSLQ 1130 QGAHSTGSSR 1140 LHDLYWQAMK 1150 TLGVQRPKLE 1160 KKDAKEIPSA 1170 TQSPISKKRK 1180 KKGFLPETKK 1190 RKKRKSEDGT 1200 PAEDGTPAAT 1210 GGSQPPSMGR 1220 KKRNRTKAKV 1230 PAQANGTPTT 1240 KSPAPGAPTR 1250 SPSTPAKSPK 1260 LQKKNQKPSQ 1270 VNGAPGSPTE 1280 PAGQKQHQKA 1290 LPKKGVLGKS 1300 PLSALARKKA 1310 RLSLVIRSPS 1320 LLQSGAKKKA QVRKAGKP

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005730 nucleolus
Cellular Component GO:0005654 nucleoplasm
Cellular Component GO:0005634 nucleus
Molecular Function GO:0070888 E-box binding
Molecular Function GO:0003723 RNA binding
Molecular Function GO:0043565 sequence-specific DNA binding
Molecular Function GO:0003714 transcription corepressor activity
Biological Process GO:0042149 cellular response to glucose starvation
Biological Process GO:0006338 chromatin remodeling
Biological Process GO:0032922 circadian regulation of gene expression
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0072332 intrinsic apoptotic signaling pathway by p53 class mediator
Biological Process GO:0045892 negative regulation of DNA-templated transcription
Biological Process GO:0001649 osteoblast differentiation
Biological Process GO:2000210 positive regulation of anoikis
Biological Process GO:0045943 positive regulation of transcription by RNA polymerase I
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0045945 positive regulation of transcription by RNA polymerase III
Biological Process GO:0006355 regulation of DNA-templated transcription
Biological Process GO:1903450 regulation of G1 to G0 transition
Biological Process GO:0042254 ribosome biogenesis
Cellular Component GO:0016020 membrane
Cellular Component GO:0042564 NLS-dependent protein nuclear import complex

Reference

[1] Yang D, Yin J, Shan L, Yi X, Zhang W et al.. Identification of lysine-lactylated substrates in gastric cancer cells.. iScience 25(7):104630. 2022 Jul 15. PMID: 35800753.

[2] Bao Q, Wan N, He Z, Cao J, Yuan W et al.. Subcellular Proteomic Mapping of Lysine Lactylation.. J Am Soc Mass Spectrom 35(12):3221-3232. 2024 Dec 4. PMID: 39569522.

[3] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[4] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.