Search Results
Overview
| Uniprot ID | Q9BQI6 |
|---|---|
| Protein Name | SMC5-SMC6 complex localization factor protein 1 |
| Gene Name | SLF1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 7 | *MEDGTPKHIIQMTG |
Function
Plays a role in the DNA damage response (DDR) pathway by regulating postreplication repair of UV-damaged DNA and genomic stability maintenance (PubMed:25931565). The SLF1-SLF2 complex acts to link RAD18 with the SMC5-SMC6 complex at replication-coupled interstrand cross-links (ICL) and DNA double-strand breaks (DSBs) sites on chromatin during DNA repair in response to stalled replication forks (PubMed:25931565). Promotes the recruitment of SLF2 and the SMC5-SMC6 complex to DNA lesions (PubMed:25931565, PubMed:36373674)
Protein Sequence
10
MEDGTPKHII
20
QMTGFKMEEK
30
EALVKLLLKL
40
DCTFIKSEKY
50
KNCTHLIAER
60
LCKSEKFLAA
70
CAAGKWILTK
80
DYIIHSAKSG
90
RWLDETTYEW
100
GYKIEKDSRY
110
SPQMQSAPKR
120
WREELKRTGA
130
PGAFHRWKVV
140
LLVRTDKRSD
150
SLIRVLEAGK
160
ANVILPKSSP
170
SGITHVIASN
180
ARIKAEKEKD
190
NFKAPFYPIQ
200
YLGDFLLEKE
210
IQNDEDSQTN
220
SVWTEHSNEE
230
TNKDFRKDAG
240
FLEMKGALRE
250
TMYRTQKEMQ
260
NHEDVNVGSI
270
LIQHHKKEKF
280
SGSSKDLKFV
290
KMRNTFGSHT
300
YENQKEIKKK
310
DEDIQRSYTL
320
RRKRKKGKES
330
NCKKGVEHEK
340
IKSTLRRHIY
350
NRDQKEMKNS
360
IFAEYAKESK
370
AMAIKTDVDV
380
VEIKNTLRKH
390
IYRAQAVRYN
400
CIRIDKQPVY
410
NVEVKNAEFP
420
RGVLNLIESL
430
IEGHFFKEAI
440
EELSTLQAHY
450
IPPVCVLHAL
460
LENVLQDNID
470
TFSGRYFHIL
480
SALLHLHPPW
490
KSPAMSRYYL
500
ELFQCPTCMK
510
GAWSLVEVLI
520
RSCLFNESFC
530
HQISENIGSK
540
VLHLTLLKFF
550
FNLIESEVQH
560
LSQKLYDWSD
570
SQNLKITGKA
580
MLLEIFWSGS
590
ETSGLLTKPV
600
NMLLEWTIYS
610
HKEKFKSNDV
620
FKHELAYLLA
630
GILGAAIDYW
640
IFLGLKMGRN
650
VMRHMSDDLG
660
SYVSLSCDDF
670
SSQELEIFIC
680
SFSSSWLQMF
690
VAEAVFKKLC
700
LQSSGSVSSE
710
PLSLQKMVYS
720
YLPALGKTGV
730
LGSGKIQVSK
740
KIGQRPCFDS
750
QRTLLMLNGT
760
KQKQVEGLPE
770
LLDLNLAKCS
780
SSLKKLKKKS
790
EGELSCSKEN
800
CPSVVKKMNF
810
HKTNLKGETA
820
LHRACINNQV
830
EKLILLLSLP
840
GIDINVKDNA
850
GWTPLHEACN
860
YGNTVCVQEI
870
LQRCPEVDLL
880
TQVDGVTPLH
890
DALSNGHVEI
900
GKLLLQHGGP
910
VLLQQRNAKG
920
ELPLDYVVSP
930
QIKEELFAIT
940
KIEDTVENFH
950
AQAEKHFHYQ
960
QLEFGSFLLS
970
RMLLNFCSIF
980
DLSSEFILAS
990
KGLTHLNELL
1000
MACKSHKETT
1010
SVHTDWLLDL
1020
YAGNIKTLQK
1030
LPHILKELPE
1040
NLKVCPGVHT
1050
EALMITLEMM
CRSVMEFS
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0005813 | centrosome |
| Cellular Component | GO:0000781 | chromosome, telomeric region |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0042405 | nuclear inclusion body |
| Cellular Component | GO:0005654 | nucleoplasm |
| Cellular Component | GO:0000786 | nucleosome |
| Cellular Component | GO:0005634 | nucleus |
| Cellular Component | GO:0035861 | site of double-strand break |
| Molecular Function | GO:0044877 | protein-containing complex binding |
| Molecular Function | GO:0031625 | ubiquitin protein ligase binding |
| Biological Process | GO:0140588 | chromatin looping |
| Biological Process | GO:0006974 | DNA damage response |
| Biological Process | GO:0000724 | double-strand break repair via homologous recombination |
| Biological Process | GO:2000781 | positive regulation of double-strand break repair |
| Biological Process | GO:0034184 | positive regulation of maintenance of mitotic sister chromatid cohesion |
| Biological Process | GO:0031334 | positive regulation of protein-containing complex assembly |
| Biological Process | GO:1990166 | protein localization to site of double-strand break |
| Biological Process | GO:0016925 | protein sumoylation |
| Biological Process | GO:0032204 | regulation of telomere maintenance |
Reference
[1] Yang YH, Wang QC, Kong J, Yang JT, Liu JF. Global profiling of lysine lactylation in human lungs.. Proteomics 23(15):e2200437. 2023 Aug. PMID: 37170646.