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Overview

Uniprot IDQ9BQK8
Protein NamePhosphatidate phosphatase LPIN3
Gene NameLPIN3
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
545 AEERSAQKEKTAAKE
551 QKEKTAAKEQQGEKT

Function

Magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis therefore regulates fatty acid metabolism

Protein Sequence

10 MNYVGQLAET 20 VFGTVKELYR 30 GLNPATLSGG 40 IDVLVVKQVD 50 GSFRCSPFHV 60 RFGKLGVLRS 70 REKVVDIELN 80 GEPVDLHMKL 90 GDSGEAFFVQ 100 ELESDDEHVP 110 PGLCTSPIPW 120 GGLSGFPSDS 130 QLGTASEPEG 140 LVMAGTASTG 150 RRKRRRRRKP 160 KQKEDAVATD 170 SSPEELEAGA 180 ESELSLPEKL 190 RPEPPGVQLE 200 EKSSLQPKDI 210 YPYSDGEWPP 220 QASLSAGELT 230 SPKSDSELEV 240 RTPEPSPLRA 250 ESHMQWAWGR 260 LPKVARAERP 270 ESSVVLEGRA 280 GATSPPRGGP 290 STPSTSVAGG 300 VDPLGLPIQQ 310 TEAGADLQPD 320 TEDPTLVGPP 330 LHTPETEESK 340 TQSSGDMGLP 350 PASKSWSWAT 360 LEVPVPTGQP 370 ERVSRGKGSP 380 KRSQHLGPSD 390 IYLDDLPSLD 400 SENAALYFPQ 410 SDSGLGARRW 420 SEPSSQKSLR 430 DPNPEHEPEP 440 TLDTVDTIAL 450 SLCGGLADSR 460 DISLEKFNQH 470 SVSYQDLTKN 480 PGLLDDPNLV 490 VKINGKHYNW 500 AVAAPMILSL 510 QAFQKNLPKS 520 TMDKLEREKM 530 PRKGGRWWFS 540 WRRRDFLAEE 550 RSAQKEKTAA 560 KEQQGEKTEV 570 LSSDDDAPDS 580 PVILEIPSLP 590 PSTPPSTPTY 600 KKSLRLSSDQ 610 IRRLNLQEGA 620 NDVVFSVTTQ 630 YQGTCRCKAT 640 IYLWKWDDKV 650 VISDIDGTIT 660 KSDALGHILP 670 QLGKDWTHQG 680 ITSLYHKIQL 690 NGYKFLYCSA 700 RAIGMADLTK 710 GYLQWVSEGG 720 CSLPKGPILL 730 SPSSLFSALH 740 REVIEKKPEV 750 FKVACLSDIQ 760 QLFLPHGQPF 770 YAAFGNRPND 780 VFAYRQVGLP 790 ESRIFTVNPR 800 GELIQELIKN 810 HKSTYERLGE 820 VVELLFPPVA 830 RGPSTDLANP 840 EYSNFCYWRE 850 PLPAVDLDTL D

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005829 cytosol
Molecular Function GO:0008195 phosphatidate phosphatase activity
Molecular Function GO:0003713 transcription coactivator activity
Biological Process GO:0032869 cellular response to insulin stimulus
Biological Process GO:0009062 fatty acid catabolic process
Biological Process GO:0045944 positive regulation of transcription by RNA polymerase II
Biological Process GO:0019432 triglyceride biosynthetic process

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.