Search Results
Overview
| Uniprot ID | Q9BQL6 |
|---|---|
| Protein Name | Fermitin family homolog 1 |
| Gene Name | FERMT1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 407 | SIAYFKNKELEQGEP |
Function
Involved in cell adhesion. Contributes to integrin activation. When coexpressed with talin, potentiates activation of ITGA2B. Required for normal keratinocyte proliferation. Required for normal polarization of basal keratinocytes in skin, and for normal cell shape. Required for normal adhesion of keratinocytes to fibronectin and laminin, and for normal keratinocyte migration to wound sites. May mediate TGF-beta 1 signaling in tumor progression
Protein Sequence
10
MLSSTDFTFA
20
SWELVVRVDH
30
PNEEQQKDVT
40
LRVSGDLHVG
50
GVMLKLVEQI
60
NISQDWSDFA
70
LWWEQKHCWL
80
LKTHWTLDKY
90
GVQADAKLLF
100
TPQHKMLRLR
110
LPNLKMVRLR
120
VSFSAVVFKA
130
VSDICKILNI
140
RRSEELSLLK
150
PSGDYFKKKK
160
KKDKNNKEPI
170
IEDILNLESS
180
PTASGSSVSP
190
GLYSKTMTPI
200
YDPINGTPAS
210
STMTWFSDSP
220
LTEQNCSILA
230
FSQPPQSPEA
240
LADMYQPRSL
250
VDKAKLNAGW
260
LDSSRSLMEQ
270
GIQEDEQLLL
280
RFKYYSFFDL
290
NPKYDAVRIN
300
QLYEQARWAI
310
LLEEIDCTEE
320
EMLIFAALQY
330
HISKLSLSAE
340
TQDFAGESEV
350
DEIEAALSNL
360
EVTLEGGKAD
370
SLLEDITDIP
380
KLADNLKLFR
390
PKKLLPKAFK
400
QYWFIFKDTS
410
IAYFKNKELE
420
QGEPLEKLNL
430
RGCEVVPDVN
440
VAGRKFGIKL
450
LIPVADGMNE
460
MYLRCDHENQ
470
YAQWMAACML
480
ASKGKTMADS
490
SYQPEVLNIL
500
SFLRMKNRNS
510
ASQVASSLEN
520
MDMNPECFVS
530
PRCAKRHKSK
540
QLAARILEAH
550
QNVAQMPLVE
560
AKLRFIQAWQ
570
SLPEFGLTYY
580
LVRFKGSKKD
590
DILGVSYNRL
600
IKIDAATGIP
610
VTTWRFTNIK
620
QWNVNWETRQ
630
VVIEFDQNVF
640
TAFTCLSADC
650
KIVHEYIGGY
660
IFLSTRSKDQ
670
NETLDEDLFH
KLTGGQD
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0030054 | cell junction |
| Cellular Component | GO:0071944 | cell periphery |
| Cellular Component | GO:0005737 | cytoplasm |
| Cellular Component | GO:0005856 | cytoskeleton |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005925 | focal adhesion |
| Cellular Component | GO:0032587 | ruffle membrane |
| Molecular Function | GO:0051015 | actin filament binding |
| Molecular Function | GO:0005178 | integrin binding |
| Biological Process | GO:0071711 | basement membrane organization |
| Biological Process | GO:0007155 | cell adhesion |
| Biological Process | GO:0007160 | cell-matrix adhesion |
| Biological Process | GO:0090162 | establishment of epithelial cell polarity |
| Biological Process | GO:0007229 | integrin-mediated signaling pathway |
| Biological Process | GO:0051546 | keratinocyte migration |
| Biological Process | GO:0043616 | keratinocyte proliferation |
| Biological Process | GO:0090090 | negative regulation of canonical Wnt signaling pathway |
| Biological Process | GO:0010629 | negative regulation of gene expression |
| Biological Process | GO:0042308 | negative regulation of protein import into nucleus |
| Biological Process | GO:2000647 | negative regulation of stem cell proliferation |
| Biological Process | GO:0051886 | negative regulation of timing of anagen |
| Biological Process | GO:0033630 | positive regulation of cell adhesion mediated by integrin |
| Biological Process | GO:0001954 | positive regulation of cell-matrix adhesion |
| Biological Process | GO:0033625 | positive regulation of integrin activation |
| Biological Process | GO:0071636 | positive regulation of transforming growth factor beta production |
| Biological Process | GO:0030511 | positive regulation of transforming growth factor beta receptor signaling pathway |
| Biological Process | GO:1903691 | positive regulation of wound healing, spreading of epidermal cells |
Reference
[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.