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Overview

Uniprot IDQ9BR39
Protein NameJunctophilin-2
Gene NameJPH2
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
647 TEARGLTKAGAKKKA

Function

Membrane-binding protein that provides a structural bridge between the plasma membrane and the sarcoplasmic reticulum and is required for normal excitation-contraction coupling in cardiomyocytes (PubMed:20095964). Provides a structural foundation for functional cross-talk between the cell surface and intracellular Ca(2+) release channels by maintaining the 12-15 nm gap between the sarcolemma and the sarcoplasmic reticulum membranes in the cardiac dyads (By similarity). Necessary for proper intracellular Ca(2+) signaling in cardiac myocytes via its involvement in ryanodine receptor-mediated calcium ion release (By similarity). Contributes to the construction of skeletal muscle triad junctions (By similarity)

Protein Sequence

10 MSGGRFDFDD 20 GGAYCGGWEG 30 GKAHGHGLCT 40 GPKGQGEYSG 50 SWNFGFEVAG 60 VYTWPSGNTF 70 EGYWSQGKRH 80 GLGIETKGRW 90 LYKGEWTHGF 100 KGRYGIRQSS 110 SSGAKYEGTW 120 NNGLQDGYGT 130 ETYADGGTYQ 140 GQFTNGMRHG 150 YGVRQSVPYG 160 MAVVVRSPLR 170 TSLSSLRSEH 180 SNGTVAPDSP 190 ASPASDGPAL 200 PSPAIPRGGF 210 ALSLLANAEA 220 AARAPKGGGL 230 FQRGALLGKL 240 RRAESRTSVG 250 SQRSRVSFLK 260 SDLSSGASDA 270 ASTASLGEAA 280 EGADEAAPFE 290 ADIDATTTET 300 YMGEWKNDKR 310 SGFGVSERSS 320 GLRYEGEWLD 330 NLRHGYGCTT 340 LPDGHREEGK 350 YRHNVLVKDT 360 KRRMLQLKSN 370 KVRQKVEHSV 380 EGAQRAAAIA 390 RQKAEIAASR 400 TSHAKAKAEA 410 AEQAALAANQ 420 ESNIARTLAR 430 ELAPDFYQPG 440 PEYQKRRLLQ 450 EILENSESLL 460 EPPDRGAGAA 470 GLPQPPRESP 480 QLHERETPRP 490 EGGSPSPAGT 500 PPQPKRPRPG 510 VSKDGLLSPG 520 AWNGEPSGEG 530 SRSVTPSEGA 540 GRRSPARPAT 550 ERMAIEALQA 560 PPAPSREPEV 570 ALYQGYHSYA 580 VRTTPPEPPP 590 FEDQPEPEVS 600 GSESAPSSPA 610 TAPLQAPTLR 620 GPEPARETPA 630 KLEPKPIIPK 640 AEPRAKARKT 650 EARGLTKAGA 660 KKKARKEAAL 670 AAEAEVEVEE 680 VPNTILICMV 690 ILLNIGLAIL FVHLLT

Gene Ontology

Classification GO ID Description
Cellular Component GO:0005789 endoplasmic reticulum membrane
Cellular Component GO:0030314 junctional membrane complex
Cellular Component GO:0014701 junctional sarcoplasmic reticulum membrane
Cellular Component GO:0005634 nucleus
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0016529 sarcoplasmic reticulum
Cellular Component GO:0030018 Z disc
Molecular Function GO:0003677 DNA binding
Molecular Function GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific
Molecular Function GO:0070300 phosphatidic acid binding
Molecular Function GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
Molecular Function GO:0080025 phosphatidylinositol-3,5-bisphosphate binding
Molecular Function GO:0032266 phosphatidylinositol-3-phosphate binding
Molecular Function GO:0005546 phosphatidylinositol-4,5-bisphosphate binding
Molecular Function GO:0070273 phosphatidylinositol-4-phosphate binding
Molecular Function GO:0010314 phosphatidylinositol-5-phosphate binding
Molecular Function GO:0001786 phosphatidylserine binding
Biological Process GO:0055074 calcium ion homeostasis
Biological Process GO:0060402 calcium ion transport into cytosol
Biological Process GO:0006351 DNA-templated transcription
Biological Process GO:0010882 regulation of cardiac muscle contraction by calcium ion signaling
Biological Process GO:0055024 regulation of cardiac muscle tissue development
Biological Process GO:0010880 regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum

Reference

[1] Cheng Z, Huang H, Li M, Chen Y. Proteomic analysis identifies PFKP lactylation in SW480 colon cancer cells.. iScience 27(1):108645. 2024 Jan 19. PMID: 38155775.