Search Results

Overview

Uniprot IDQ9BR76
Protein NameCoronin-1B
Gene NameCORO1B
OrganismHomo sapiens

Kla Sites from experimental identification

Position Flanking peptide
339 CEIARFYKLHERKCE
355 IVMTVPRKSDLFQDD
400 REAYVPSKQRDLKIS
468 RALRALVKEQGDRIC

Function

Regulates leading edge dynamics and cell motility in fibroblasts. May be involved in cytokinesis and signal transduction (By similarity)

Protein Sequence

10 MSFRKVVRQS 20 KFRHVFGQPV 30 KNDQCYEDIR 40 VSRVTWDSTF 50 CAVNPKFLAV 60 IVEASGGGAF 70 LVLPLSKTGR 80 IDKAYPTVCG 90 HTGPVLDIDW 100 CPHNDEVIAS 110 GSEDCTVMVW 120 QIPENGLTSP 130 LTEPVVVLEG 140 HTKRVGIIAW 150 HPTARNVLLS 160 AGCDNVVLIW 170 NVGTAEELYR 180 LDSLHPDLIY 190 NVSWNHNGSL 200 FCSACKDKSV 210 RIIDPRRGTL 220 VAEREKAHEG 230 ARPMRAIFLA 240 DGKVFTTGFS 250 RMSERQLALW 260 DPENLEEPMA 270 LQELDSSNGA 280 LLPFYDPDTS 290 VVYVCGKGDS 300 SIRYFEITEE 310 PPYIHFLNTF 320 TSKEPQRGMG 330 SMPKRGLEVS 340 KCEIARFYKL 350 HERKCEPIVM 360 TVPRKSDLFQ 370 DDLYPDTAGP 380 EAALEAEEWV 390 SGRDADPILI 400 SLREAYVPSK 410 QRDLKISRRN 420 VLSDSRPAMA 430 PGSSHLGAPA 440 STTTAADATP 450 SGSLARAGEA 460 GKLEEVMQEL 470 RALRALVKEQ 480 GDRICRLEEQ LGRMENGDA

Gene Ontology

Classification GO ID Description
Molecular Function GO:0042802 identical protein binding
Biological Process GO:0030036 actin cytoskeleton organization
Biological Process GO:0090135 actin filament branching
Biological Process GO:0051017 actin filament bundle assembly
Cellular Component GO:0005884 actin filament
Cellular Component GO:0031252 cell leading edge
Cellular Component GO:0071944 cell periphery
Cellular Component GO:0005737 cytoplasm
Cellular Component GO:0005829 cytosol
Cellular Component GO:0070062 extracellular exosome
Cellular Component GO:0005925 focal adhesion
Cellular Component GO:0098978 glutamatergic synapse
Cellular Component GO:0030027 lamellipodium
Cellular Component GO:0048471 perinuclear region of cytoplasm
Cellular Component GO:0005886 plasma membrane
Cellular Component GO:0001725 stress fiber
Molecular Function GO:0051015 actin filament binding
Molecular Function GO:0071933 Arp2/3 complex binding
Molecular Function GO:0045296 cadherin binding
Biological Process GO:0007015 actin filament organization
Biological Process GO:0016477 cell migration
Biological Process GO:0036120 cellular response to platelet-derived growth factor stimulus
Biological Process GO:0035767 endothelial cell chemotaxis
Biological Process GO:0034316 negative regulation of Arp2/3 complex-mediated actin nucleation
Biological Process GO:0071672 negative regulation of smooth muscle cell chemotaxis
Biological Process GO:2000394 positive regulation of lamellipodium morphogenesis
Biological Process GO:1902463 protein localization to cell leading edge
Biological Process GO:0034315 regulation of Arp2/3 complex-mediated actin nucleation
Biological Process GO:0031529 ruffle organization
Biological Process GO:0042060 wound healing

Reference

[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.

[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.

[3] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[4] He J, Lai T, Zhou Z, Yang H, Lei Z et al.. Multiomics profiling reveals the involvement of protein lactylation in nonhomologous end joining pathway conferring radioresistance in lung adenocarcinoma cell.. Sci Rep 15(1):24651. 2025 Jul 9. PMID: 40634431.

[5] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.