Search Results
Overview
| Uniprot ID | Q9BRF8 |
|---|---|
| Protein Name | Serine/threonine-protein phosphatase CPPED1 |
| Gene Name | CPPED1 |
| Organism | Homo sapiens |
Kla Sites from experimental identification
| Position | Flanking peptide |
|---|---|
| 109 | TEQTEDLKRVLRAVD |
| 287 | VVVVTAEKIVHRYYS |
Function
Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes
Protein Sequence
10
MSAAEAGGVF
20
HRARGRTLAA
30
FPAEKESEWK
40
GPFYFILGAD
50
PQFGLIKAWS
60
TGDCDNGGDE
70
WEQEIRLTEQ
80
AVQAINKLNP
90
KPKFFVLCGD
100
LIHAMPGKPW
110
RTEQTEDLKR
120
VLRAVDRAIP
130
LVLVSGNHDI
140
GNTPTAETVE
150
EFCRTWGDDY
160
FSFWVGGVLF
170
LVLNSQFYEN
180
PSKCPSLKQA
190
QDQWLDEQLS
200
IARQRHCQHA
210
IVFQHIPLFL
220
ESIDEDDDYY
230
FNLSKSTRKK
240
LADKFIHAGV
250
KVVFSGHYHR
260
NAGGTYQNLD
270
MVVSSAIGCQ
280
LGRDPHGLRV
290
VVVTAEKIVH
300
RYYSLDELSE
310
KGIEDDLMDL
IKKK
Gene Ontology
| Classification | GO ID | Description |
|---|---|---|
| Cellular Component | GO:0035578 | azurophil granule lumen |
| Cellular Component | GO:0005829 | cytosol |
| Cellular Component | GO:0005576 | extracellular region |
| Cellular Component | GO:0005886 | plasma membrane |
| Molecular Function | GO:0046872 | metal ion binding |
| Molecular Function | GO:0004722 | protein serine/threonine phosphatase activity |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.
[2] Hong H, Chen X, Wang H, Gu X, Yuan Y et al.. Global profiling of protein lysine lactylation and potential target modified protein analysis in hepatocellular carcinoma.. Proteomics 23(9):e2200432. 2023 May. PMID: 36625413.