Search Results

Overview

Uniprot ID	Q9BRJ6
Protein Name	Protein cholesin
Gene Name	CHLSN
Organism	Homo sapiens

Kla Sites from experimental identification

Position	Flanking peptide
15	VPEVTEKKNKKLKKA
21	KKNKKLKKASAEGPL
7	*MAKQKRKVPEVTEK

Function

Hormone secreted from the intestine in response to cholesterol, where it acts to inhibit cholesterol synthesis in the liver and VLDL secretion,leading to a reduction in circulating cholesterol levels. Acts through binding to its receptor, GPR146

Protein Sequence

10 MAKQKRKVPE 20 VTEKKNKKLK 30 KASAEGPLLG 40 PEAAPSGEGA 50 GSKGEAVLRP 60 GLDAEPELSP 70 EEQRVLERKL 80 KKERKKEERQ 90 RLREAGLVAQ 100 HPPARRSGAE 110 LALDYLCRWA 120 QKHKNWRFQK 130 TRQTWLLLHM 140 YDSDKVPDEH 150 FSTLLAYLEG 160 LQGRARELTV 170 QKAEALMREL 180 DEEGSDPPLP 190 GRAQRIRQVL QLLS

Gene Ontology

Classification	GO ID	Description
Cellular Component	GO:0005615	extracellular space
Molecular Function	GO:0005179	hormone activity
Molecular Function	GO:0003723	RNA binding
Biological Process	GO:0045541	negative regulation of cholesterol biosynthetic process

Reference

[1] He C, Zhang J, Bai X, Lu C, Zhang K. Lysine lactylation-based insight to understanding the characterization of cervical cancer.. Biochim Biophys Acta Mol Basis Dis 1870(7):167356. 2024 Oct. PMID: 39025375.

[2] Guo X, Ren X, Yan C, Huang H. Quantitative Proteomics Reveals the Role of Lysine Lactylation in Lenalidomide-Resistance in Multiple Myeloma Cells.. ACS Chem Biol 20(7):1728-1738. 2025 Jul 18. PMID: 40590393.

[3] Wu Q, Li Z, Gong T, Zheng X, Zhou X et al.. Porphyromonas gingivalis infection induces lysine lactylation reprogramming in human umbilical vein endothelial cells.. Front Cell Infect Microbiol 16:1706727. 2026. PMID: 41696360.