Overview
| Uniprot ID | Q9BRK3 |
|---|
| Protein Name | Matrix remodeling-associated protein 8 |
|---|
| Gene Name | MXRA8 |
|---|
| Organism | Homo sapiens |
|---|
Kla Sites from experimental identification
| Position |
Flanking peptide |
| 434 |
AKYIDLDKGFRKENC |
Function
Transmembrane protein which can modulate activity of various signaling pathways, probably via binding to integrin ITGAV:ITGB3 (PubMed:22492581, PubMed:23386276). Mediates heterophilic cell-cell interactions in vitro (By similarity). Inhibits osteoclastogenesis downstream of TNFSF11/RANKL and CSF1, where it may function by attenuating signaling via integrin ITGB3 and MAP kinase p38 (By similarity). Plays a role in cartilage formation where it promotes proliferation and maturation of growth plate chondrocytes (By similarity). Stimulates formation of primary cilia in chondrocytes (By similarity). Enhances expression of genes involved in the hedgehog signaling pathway in chondrocytes, including the hedgehog signaling molecule IHH; may also promote signaling via the PTHLH/PTHrP pathway (By similarity). Plays a role in angiogenesis where it suppresses migration of endothelial cells and also promotes their apoptosis (PubMed:23386276). Inhibits VEGF-induced activation of AKT and p38 MAP kinase in endothelial cells (PubMed:23386276). Also inhibits VTN (vitronectin)-mediated integrin ITGAV:ITGB3 signaling and activation of PTK2/FAK (PubMed:23386276). May play a role in the maturation and maintenance of the blood-brain barrier (By similarity)
Protein Sequence
10
MALPSRILLW
20
KLVLLQSSAV
30
LLHSGSSVPA
40
AAGSSVVSES
50
AVSWEAGARA
60
VLRCQSPRMV
70
WTQDRLHDRQ
80
RVLHWDLRGP
90
GGGPARRLLD
100
LYSAGEQRVY
110
EARDRGRLEL
120
SASAFDDGNF
130
SLLIRAVEET
140
DAGLYTCNLH
150
HHYCHLYESL
160
AVRLEVTDGP
170
PATPAYWDGE
180
KEVLAVARGA
190
PALLTCVNRG
200
HVWTDRHVEE
210
AQQVVHWDRQ
220
PPGVPHDRAD
230
RLLDLYASGE
240
RRAYGPLFLR
250
DRVAVGADAF
260
ERGDFSLRIE
270
PLEVADEGTY
280
SCHLHHHYCG
290
LHERRVFHLT
300
VAEPHAEPPP
310
RGSPGNGSSH
320
SGAPGPDPTL
330
ARGHNVINVI
340
VPESRAHFFQ
350
QLGYVLATLL
360
LFILLLVTVL
370
LAARRRRGGY
380
EYSDQKSGKS
390
KGKDVNLAEF
400
AVAAGDQMLY
410
RSEDIQLDYK
420
NNILKERAEL
430
AHSPLPAKYI
440
DLDKGFRKEN
CK
Gene Ontology
| Classification |
GO ID |
Description |
| Cellular Component |
GO:0005923 |
bicellular tight junction |
| Cellular Component |
GO:0009986 |
cell surface |
| Cellular Component |
GO:0060170 |
ciliary membrane |
| Cellular Component |
GO:0005788 |
endoplasmic reticulum lumen |
| Cellular Component |
GO:0070062 |
extracellular exosome |
| Cellular Component |
GO:0005634 |
nucleus |
| Biological Process |
GO:0007155 |
cell adhesion |
| Biological Process |
GO:0030154 |
cell differentiation |
| Biological Process |
GO:0060857 |
establishment of glial blood-brain barrier |
Reference
[1] Yang Z, Yan C, Ma J, Peng P, Ren X et al.. Lactylome analysis suggests lactylation-dependent mechanisms of metabolic adaptation in hepatocellular carcinoma.. Nat Metab 5(1):61-79. 2023 Jan. PMID: 36593272.